{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:36:29Z","timestamp":1791556589222,"version":"4.3.4"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alexander Jansons Foundation"},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Cardiovascular Biomedical Research Unit of Royal Brompton"},{"name":"Harefield NHS Foundation Trust"},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>There is an important need for better biomarkers to predict left ventricular (LV) remodelling in dilated cardiomyopathy (DCM). We undertook a comprehensive assessment of cardiac structure and myocardial composition to determine predictors of remodelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Prospective study of patients with recent-onset DCM with cardiovascular magnetic resonance (CMR) assessment of ventricular structure and function, extracellular volume (T1 mapping), myocardial strain, myocardial scar (late gadolinium enhancement) and contractile reserve (dobutamine stress). Regression analyses were used to evaluate predictors of change in LV ejection fraction (LVEF) over 12\u2009months. We evaluated 56 participants (34 DCM patients, median LVEF 43%; 22 controls). Absolute LV contractile reserve predicted change in LVEF (1% increase associated with 0.4% increase in LVEF at 12\u2009months, P = 0.02). Baseline myocardial strain (P = 0.39 global longitudinal strain), interstitial myocardial fibrosis (P = 0.41), replacement myocardial fibrosis (P = 0.25), and right ventricular contractile reserve (P = 0.17) were not associated with LV reverse remodelling. There was a poor correlation between contractile reserve and either LV extracellular volume fraction (r = \u22120.22, P = 0.23) or baseline LVEF (r = 0.07, P = 0.62). Men were more likely to experience adverse LV remodelling (P = 0.01) but age (P = 0.88) and disease-modifying heart failure medication (beta-blocker, P = 0.28; angiotensin-converting enzyme inhibitor, P = 0.92) did not predict follow-up LVEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Substantial recovery of LV function occurs within 12\u2009months in most patients with recent-onset DCM. Women had the greatest improvement in LVEF. A low LV contractile reserve measured by dobutamine stress CMR appears to identify patients whose LVEF is less likely to recover.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1734","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T01:44:17Z","timestamp":1581644657000},"page":"1160-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Predictors of Left Ventricular Remodelling in Patients with Dilated Cardiomyopathy \u2013 A Cardiovascular Magnetic Resonance Study"],"prefix":"10.1093","volume":"22","author":[{"given":"Upasana","family":"Tayal","sequence":"first","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Wage","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Newsome","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, London School of Hygiene and Tropical Medicine , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasamy","family":"Manivarmane","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemil","family":"Izgi","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Muthumala","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital and St Bartholomew\u2019s Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason N.","family":"Dungu","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre , Basildon ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Assomull","sequence":"additional","affiliation":[{"name":"Imperial College NHS Trust \u00a0","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Hatipoglu","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Halliday","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit S.","family":"Lota","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Ware","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]},{"name":"MRC London Institute of Medical Sciences , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gregson","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, London School of Hygiene and Tropical Medicine , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frenneaux","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"University of East Anglia , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Cook","sequence":"additional","affiliation":[{"name":"Duke-National University of Singapore \u00a0","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudley J.","family":"Pennell","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Scott","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K.","family":"Prasad","sequence":"additional","affiliation":[{"name":"National Heart Lung Institute, Imperial College London \u00a0","place":["UK"]},{"name":"Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"2026011721360700700_ejhf1734-bib-0001","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMoa1608029","article-title":"Defibrillator implantation in patients with nonischemic systolic heart failure","volume":"375","author":"Kober","year":"2016","journal-title":"N Engl J Med"},{"key":"2026011721360700700_ejhf1734-bib-0002","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/jama.2013.1363","article-title":"Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy","volume":"309","author":"Gulati","year":"2013","journal-title":"JAMA"},{"key":"2026011721360700700_ejhf1734-bib-0003","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1067\/mhj.2003.105","article-title":"Marked improvement in left ventricular ejection fraction during long-term beta-blockade in patients with chronic heart failure: clinical correlates and prognostic significance","volume":"145","author":"Metra","year":"2003","journal-title":"Am Heart J"},{"key":"2026011721360700700_ejhf1734-bib-0004","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12947-015-0009-4","article-title":"Prediction of left ventricular reverse remodeling after therapy with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and \u03b2 blockers in patients with idiopathic dilated cardiomyopathy","volume":"13","author":"Matsumura","year":"2015","journal-title":"Cardiovasc Ultrasound"},{"key":"2026011721360700700_ejhf1734-bib-0005","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0002-9149(99)00414-2","article-title":"Prevalence, predictors, and prognosis of reversal of maladaptive remodeling with intensive medical therapy in idiopathic dilated cardiomyopathy","volume":"84","author":"Kawai","year":"1999","journal-title":"Am J Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0006","first-page":"405","article-title":"Prevalence and clinical predictors of reverse remodeling in patients with dilated cardiomyopathy","volume":"16","author":"Arad","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"2026011721360700700_ejhf1734-bib-0007","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1378\/chest.122.2.542","article-title":"Dobutamine gated blood pool scintigraphy predicts the improvement of cardiac sympathetic nerve activity, cardiac function, and symptoms after treatment in patients with dilated cardiomyopathy","volume":"122","author":"Kasama","year":"2002","journal-title":"Chest"},{"key":"2026011721360700700_ejhf1734-bib-0008","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.repc.2015.11.014","article-title":"Prevalence, predictors and prognosis of ventricular reverse remodeling in idiopathic dilated cardiomyopathy","volume":"35","author":"Amorim","year":"2016","journal-title":"Rev Port Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0009","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIR.0b013e31829e8807","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"2026011721360700700_ejhf1734-bib-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/ERP-17-0054","article-title":"Contractile reserve as a predictor of prognosis in patients with non-ischaemic systolic heart failure and dilated cardiomyopathy: a systematic review and meta-analysis","volume":"5","author":"Waddingham","year":"2018","journal-title":"Echo Res Pract"},{"key":"2026011721360700700_ejhf1734-bib-0011","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/ehjci\/jev069","article-title":"Bi-ventricular contractile reserve offers an incremental prognostic value for patients with dilated cardiomyopathy","volume":"16","author":"Matsumoto","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026011721360700700_ejhf1734-bib-0012","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/10976640600572889","article-title":"Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance","volume":"8","author":"Maceira","year":"2006","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026011721360700700_ejhf1734-bib-0013","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1532-429X-15-92","article-title":"Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement","volume":"15","author":"Moon","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026011721360700700_ejhf1734-bib-0014","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mrm.20110","article-title":"Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart","volume":"52","author":"Messroghli","year":"2004","journal-title":"Magn Reson Med"},{"key":"2026011721360700700_ejhf1734-bib-0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12968-016-0308-4","article-title":"Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: a comprehensive review","volume":"18","author":"Haaf","year":"2016","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026011721360700700_ejhf1734-bib-0016","doi-asserted-by":"crossref","first-page":"O50","DOI":"10.1186\/1532-429X-18-S1-O50","article-title":"Accelerating cine DENSE using a zonal excitation","volume":"18","author":"Scott","year":"2016","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026011721360700700_ejhf1734-bib-0017","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10334-019-00735-5","article-title":"The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy","volume":"32","author":"Tayal","year":"2019","journal-title":"MAGMA"},{"key":"2026011721360700700_ejhf1734-bib-0018","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1109\/TMI.2012.2195194","article-title":"Automated motion estimation for 2-D cine DENSE MRI","volume":"31","author":"Gilliam","year":"2012","journal-title":"IEEE Trans Med Imaging"},{"key":"2026011721360700700_ejhf1734-bib-0019","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1109\/TMI.2006.884215","article-title":"Tracking myocardial motion from cine DENSE images using spatiotemporal phase unwrapping and temporal fitting","volume":"26","author":"Spottiswoode","year":"2007","journal-title":"IEEE Trans Med Imaging"},{"key":"2026011721360700700_ejhf1734-bib-0020","author":"Gilliam"},{"key":"2026011721360700700_ejhf1734-bib-0021","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/hrt.81.5.523","article-title":"Low dose dobutamine stress echocardiography predicts the improvement of left ventricular systolic function in dilated cardiomyopathy","volume":"81","author":"Kitaoka","year":"1999","journal-title":"Heart"},{"key":"2026011721360700700_ejhf1734-bib-0022","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1161\/01.CIR.0000097111.00170.7B","article-title":"Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST)","volume":"108","author":"Eichhorn","year":"2003","journal-title":"Circulation"},{"key":"2026011721360700700_ejhf1734-bib-0023","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/ejhf.787","article-title":"Multidimensional contractile reserve predicts adverse outcome in patients with severe systolic heart failure: a 4-year follow-up study","volume":"19","author":"Paraskevaidis","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026011721360700700_ejhf1734-bib-0024","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.amjcard.2003.09.055","article-title":"Prognostic usefulness of echocardiographic dobutamine in younger (14 to 25\u2009years) and older (40 to 55\u2009years) patients with idiopathic dilated cardiomyopathy","volume":"93","author":"Paraskevaidis","year":"2004","journal-title":"Am J Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0025","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/ehjci\/jev327","article-title":"Significant prognostic impact of improvement in ventriculo-arterial coupling induced by dobutamine stress on cardiovascular outcome for patients with dilated cardiomyopathy","volume":"17","author":"Matsumoto","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026011721360700700_ejhf1734-bib-0026","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0735-1097(01)01194-9","article-title":"Dobutamine echocardiographic study in patients with nonischemic dilated cardiomyopathy and prognostically borderline values of peak exercise oxygen consumption: 18-month follow-up study","volume":"37","author":"Paraskevaidis","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0027","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1388-9842(01)00208-2","article-title":"Dobutamine echocardiography in idiopathic dilated cardiomyopathy: clinical and prognostic implications","volume":"4","author":"Pinamonti","year":"2002","journal-title":"Eur J Heart Fail"},{"key":"2026011721360700700_ejhf1734-bib-0028","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0002-9149(01)02116-6","article-title":"Prognostic significance of the dobutamine echocardiography test in idiopathic dilated cardiomyopathy","volume":"88","author":"Pratali","year":"2001","journal-title":"Am J Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0029","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.amjcard.2008.06.060","article-title":"Usefulness of dobutamine-induced changes of the two-dimensional longitudinal deformation predict clinical and neurohumoral improvement in men after levosimendan treatment in acutely decompensated chronic heart failure","volume":"102","author":"Paraskevaidis","year":"2008","journal-title":"Am J Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0030","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0735-1097(99)00371-X","article-title":"Myocardial contractile reserve on dobutamine echocardiography predicts late spontaneous improvement in cardiac function in patients with recent onset idiopathic dilated cardiomyopathy","volume":"34","author":"Naqvi","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0031","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/ejhf.768","article-title":"The importance of myocardial contractile reserve in predicting response to cardiac resynchronization therapy","volume":"19","author":"Kloosterman","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026011721360700700_ejhf1734-bib-0032","article-title":"Impact of etiology on the outcomes in heart failure patients treated with cardiac resynchronization therapy: a meta-analysis","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"2026011721360700700_ejhf1734-bib-0033","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11897-013-0157-5","article-title":"Epidemiology and natural history of recovery of left ventricular function in recent onset dilated cardiomyopathies","volume":"10","author":"Givertz","year":"2013","journal-title":"Curr Heart Fail Rep"},{"key":"2026011721360700700_ejhf1734-bib-0034","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.amjcard.2012.08.056","article-title":"Left ventricular reverse remodeling in long-term (&gt;12\u2009years) survivors with idiopathic dilated cardiomyopathy","volume":"111","author":"Matsumura","year":"2013","journal-title":"Am J Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0035","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","article-title":"Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy","volume":"61","author":"Kubanek","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0036","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001504","article-title":"Persistent recovery of normal left ventricular function and dimension in idiopathic dilated cardiomyopathy during long-term follow-up: does real healing exist?","volume":"4","author":"Merlo","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2026011721360700700_ejhf1734-bib-0037","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jacc.2011.05.033","article-title":"Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study","volume":"58","author":"McNamara","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0038","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jacc.2010.11.030","article-title":"Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment","volume":"57","author":"Merlo","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0039","doi-asserted-by":"crossref","first-page":"e003788","DOI":"10.1161\/CIRCHEARTFAILURE.116.003788","article-title":"Abnormal global longitudinal strain predicts future deterioration of left ventricular function in heart failure patients with a recovered left ventricular ejection fraction","volume":"10","author":"Adamo","year":"2017","journal-title":"Circ Heart Fail"},{"key":"2026011721360700700_ejhf1734-bib-0040","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cardfail.2017.04.005","article-title":"Advancing the science of myocardial recovery with mechanical circulatory support: a working group of the National, Heart, Lung and Blood Institute","volume":"23","author":"Drakos","year":"2017","journal-title":"J Card Fail"},{"key":"2026011721360700700_ejhf1734-bib-0041","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejheart.2004.01.017","article-title":"Relation of myocardial histomorphometric features and left ventricular contractile reserve assessed by high-dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy","volume":"7","author":"Otasevic","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"2026011721360700700_ejhf1734-bib-0042","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1161\/01.CIR.0000095029.57483.60","article-title":"Gadolinium cardiovascular magnetic resonance predicts reversible myocardial dysfunction and remodeling in patients with heart failure undergoing beta-blocker therapy","volume":"108","author":"Bello","year":"2003","journal-title":"Circulation"},{"key":"2026011721360700700_ejhf1734-bib-0043","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.yjmcc.2009.06.001","article-title":"Extracellular matrix remodeling during the progression of volume overload-induced heart failure","volume":"48","author":"Hutchinson","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0044","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jamacardio.2016.1356","article-title":"Heart failure \u2013 a new phenotype emerges","volume":"1","author":"Wilcox","year":"2016","journal-title":"JAMA Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0045","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.echo.2012.05.002","article-title":"Differential effects of dobutamine versus treadmill exercise on left ventricular volume and wall stress","volume":"25","author":"Mehrotra","year":"2012","journal-title":"J Am Soc Echocardiogr"},{"key":"2026011721360700700_ejhf1734-bib-0046","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jjcc.2017.02.005","article-title":"Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy","volume":"70","author":"Morimoto","year":"2017","journal-title":"J Cardiol"},{"key":"2026011721360700700_ejhf1734-bib-0047","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)32484-X","article-title":"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial","volume":"393","author":"Halliday","year":"2019","journal-title":"Lancet"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejhf.1734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.1734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.1734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/22\/7\/1160\/66111465\/eurjhf_22_7_1160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/22\/7\/1160\/66111465\/eurjhf_22_7_1160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:37:25Z","timestamp":1768703845000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/22\/7\/1160\/8385200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,2,13]]},"published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.1734","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,2,13]]},"assertion":[{"value":"2019-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}