{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:41:37Z","timestamp":1792885297692,"version":"4.5.0"},"reference-count":188,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":2123,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC CoG 818715"],"award-info":[{"award-number":["ERC CoG 818715"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["SECRETE-HF"],"award-info":[{"award-number":["SECRETE-HF"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research","award":["917.13.350"],"award-info":[{"award-number":["917.13.350"]}],"id":[{"id":"https:\/\/ror.org\/04jsz6e67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Netherlands Heart Foundation","award":["2017\u201311"],"award-info":[{"award-number":["2017\u201311"]}]},{"name":"Netherlands Heart Foundation","award":["2014\u201340"],"award-info":[{"award-number":["2014\u201340"]}]},{"name":"Netherlands Heart Foundation","award":["2017\u201321"],"award-info":[{"award-number":["2017\u201321"]}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["ERC CoG 818715"],"award-info":[{"award-number":["ERC CoG 818715"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["SECRETE\u2010HF"],"award-info":[{"award-number":["SECRETE\u2010HF"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The use of circulating biomarkers for heart failure (HF) is engrained in contemporary cardiovascular practice and provides objective information about various pathophysiological pathways associated with HF syndrome. However, biomarker profiles differ considerably among women and men. For instance, in the general population, markers of cardiac stretch (natriuretic peptides) and fibrosis (galectin-3) are higher in women, whereas markers of cardiac injury (cardiac troponins) and inflammation (sST2) are higher in men. Such differences may reflect sex-specific pathogenic processes associated with HF risk, but may also arise as a result of differences in sex hormone profiles and fat distribution. From a clinical perspective, sex-related differences in biomarker levels may affect the objectivity of biomarkers in HF management because what is considered to be \u2018normal\u2019 in one sex may not be so in the other. The objectives of this review are, therefore: (i) to examine the sex-specific dynamics of clinically relevant HF biomarkers in the general population, as well as in HF patients; (ii) to discuss the overlap between sex-related and obesity-related effects, and (iii) to identify knowledge gaps to stimulate research on sex-related differences in HF.<\/jats:p>","DOI":"10.1002\/ejhf.1771","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T06:29:17Z","timestamp":1585290557000},"page":"775-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Sex-Related Differences in Contemporary Biomarkers for Heart Failure: A Review"],"prefix":"10.1093","volume":"22","author":[{"given":"Navin","family":"Suthahar","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Cardiology , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.G.","family":"Meems","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Cardiology , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, and Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A.","family":"de Boer","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Cardiology , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"2026011721352548100_ejhf1771-bib-0001","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/ejhf.872","article-title":"Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. 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