{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:59:20Z","timestamp":1790668760230,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>MitraClip therapy for the treatment of functional mitral regurgitation (FMR) is an increasingly used intervention for high-risk surgical patients. The aim of this observational study was to assess the impact of residual mitral regurgitation (rMR) at discharge on long-term outcome after MitraClip therapy in patients with FMR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Overall, 458 patients (mean age 73.8\u2009\u00b1\u20098.9\u2009years) underwent MitraClip implantation between September 2008 and December 2017. The impact of rMR\u2009\u2264\u20091+ at discharge (n = 251) was retrospectively compared to patients graded as rMR 2+ (n = 173) and rMR \u22653+ (n = 34) at discharge. Median follow-up time was 5.09\u2009years (5.00\u20135.26) with maximum follow-up of 10.02\u2009years. The primary outcome was survival, and Kaplan\u2013Meier analyses revealed significant differences among all rMR subgroups with highest survival rates for rMR\u2009\u2264\u20091+ patients. This was further confirmed by composite outcome analyses (P\u2009&amp;lt;\u20090.02). The inferior outcomes of rMR 2+ and rMR\u2009\u2265\u20093+ at discharge were confirmed by increased adjusted hazard ratios when rMR 2+ (1.54, P = 0.0039) and rMR\u2009\u2265\u20093+ (2.16, P = 0.011) were compared to rMR\u2009\u2264\u20091+. Moreover, patients with stable rMR\u2009\u2264\u20091+ grades within 12\u2009months showed significantly higher survival rates compared to patients with rMR\u2009\u2264\u20091+ at discharge and rMR\u2009\u2265\u20092+ at 12-month follow-up or rMR\u2009\u2265\u20092+ at discharge and 12-month follow-up (P = 0.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with optimal and durable rMR\u2009\u2264\u20091+ at discharge and 12-month follow-up showed better outcome compared to patients with rMR 2+ and rMR\u2009\u2265\u20093+. Treatment success and durability characterized by rMR\u2009\u2264\u20091+ at discharge and 12\u2009months seem to be important factors for long-term outcomes, which has to be further confirmed by prospective randomized trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1774","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T06:46:45Z","timestamp":1586328405000},"page":"1840-1848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["The Impact of Residual Mitral Regurgitation After MitraClip Therapy in Functional Mitral Regurgitation"],"prefix":"10.1093","volume":"22","author":[{"given":"Daniel","family":"Reichart","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center , Hamburg 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