{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:14:24Z","timestamp":1769019264375,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":4092,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["OTKA 105555"],"award-info":[{"award-number":["OTKA 105555"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>There are limited and contradictory data on the effects of CRT with implantable cardioverter defibrillator (CRT-D) on mortality as compared with CRT with pacemaker (CRT-P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We evaluated the long-term outcome of patients implanted with a CRT-D or CRT-P device in our high-volume single-centre experience. Data on all-cause mortality were derived from clinic visits and the Hungarian National Healthcare Fund Death Registry. Kaplan\u2013Meier survival analyses and multivariate Cox regression models were used to evaluate all-cause mortality in patients with CRT-D vs. CRT-P, stratified by the aetiology of cardiomyopathy. From 2000 to 2011, 1122 CRT devices, 693 CRT-P (LVEF 28.2\u2009\u00b1\u20097.4%) and 429 CRT-D (LVEF 27.6\u2009\u00b1\u20096.4%), were implanted at our centre. During the median follow-up of 28 months, 379 patients died from any cause, 250 patients (36%) with an implanted CRT-P and 129 patients (30%) with an implanted CRT-D. There was no evidence of mortality benefit in patients implanted with a CRT-D compared with a CRT-P in the total cohort [hazard ratio (HR) 0.98, 95% confidence interval (CI) 0.73\u20131.32, P\u2009=\u20090.884]. In patients with ischaemic cardiomyopathy, CRT-D treatment was associated with a significant 30% risk reduction in all-cause mortality compared with an implanted CRT-P (HR 0.70, 95% CI 0.51\u20130.97, P\u2009=\u20090.03). In non-ischaemic patients, there was no mortality benefit of CRT-D over CRT-P (HR 0.98, 95% CI 0.73\u20131.32, P\u2009=\u20090.894, interaction P-value\u2009=\u20090.15).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In heart failure patients with ischaemic cardiomyopathy, CRT-D was associated with a mortality benefit compared with CRT-P, but no benefit of CRT-D over CRT-P in mortality was observed in non-ischaemic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.185","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T03:58:49Z","timestamp":1415332729000},"page":"1323-1330","source":"Crossref","is-referenced-by-count":61,"title":["Effect of Cardiac Resynchronization Therapy with Implantable Cardioverter Defibrillator versus Cardiac Resynchronization Therapy with Pacemaker on Mortality in Heart Failure Patients: Results of a High-Volume, Single-Centre Experience"],"prefix":"10.1093","volume":"16","author":[{"given":"Valentina","family":"Kutyifa","sequence":"first","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]},{"name":"University of Rochester, Medical Center , Rochester, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Geller","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bogyi","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endre","family":"Zima","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet K.","family":"Aktas","sequence":"additional","affiliation":[{"name":"University of Rochester, Medical Center , Rochester, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin Evren","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Becker","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien Klaudia","family":"Nagy","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Kosztin","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Szilagyi","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Merkely","sequence":"additional","affiliation":[{"name":"Semmelweis University, Heart and Vascular Center , Budapest ,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"2026011921132269500_ejhf185-bib-0001","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N Engl J Med"},{"key":"2026011921132269500_ejhf185-bib-0002","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"2026011921132269500_ejhf185-bib-0003","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"Cardiac Resynchronization-Heart Failure Study I. The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"2026011921132269500_ejhf185-bib-0004","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"2026011921132269500_ejhf185-bib-0005","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/bmj.39343.511389.BE","article-title":"Combined resynchronisation and implantable defibrillator therapy in left ventricular dysfunction: Bayesian network meta-analysis of randomised controlled trials","volume":"335","author":"Lam","year":"2007","journal-title":"BMJ"},{"key":"2026011921132269500_ejhf185-bib-0006","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ejheart.2005.11.014","article-title":"Cardiac resynchronisation for patients with heart failure due to left ventricular systolic dysfunction \u2013 a systematic review and meta-analysis","volume":"8","author":"Freemantle","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"2026011921132269500_ejhf185-bib-0007","doi-asserted-by":"crossref","first-page":"381","DOI":"10.7326\/0003-4819-141-5-200409070-00101","article-title":"Systematic review: cardiac resynchronization in patients with symptomatic heart failure","volume":"141","author":"McAlister","year":"2004","journal-title":"Ann Intern Med"},{"key":"2026011921132269500_ejhf185-bib-0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta9360","article-title":"The clinical and cost-effectiveness of implantable cardioverter defibrillators: a systematic review","volume":"9","author":"Bryant","year":"2005","journal-title":"Health Technol Assess"},{"key":"2026011921132269500_ejhf185-bib-0009","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/europace\/euq041","article-title":"Tracing the European course of cardiac resynchronization therapy from 2006 to 2008","volume":"12","author":"Merkely","year":"2010","journal-title":"Europace"},{"key":"2026011921132269500_ejhf185-bib-0010","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/eurheartj\/ehn309","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)","volume":"29","author":"Dickstein","year":"2008","journal-title":"Eur Heart J"},{"key":"2026011921132269500_ejhf185-bib-0011","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2008.02.032","article-title":"ACC\/AHA\/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC\/AHA\/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons","volume":"51","author":"Epstein","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026011921132269500_ejhf185-bib-0012","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/eurjhf\/hfs105","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC","volume":"14","author":"McMurray","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2026011921132269500_ejhf185-bib-0013","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10198-010-0252-4","article-title":"The impact of disease severity on EQ-5D and SF-6D utility discrepancies in chronic heart failure","volume":"12","author":"Kontodimopoulos","year":"2011","journal-title":"Eur J Health Econ"},{"key":"2026011921132269500_ejhf185-bib-0014","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"2026011921132269500_ejhf185-bib-0015","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.hrthm.2011.01.016","article-title":"Long-term experience with coronary sinus side branch stenting to stabilize left ventricular electrode position","volume":"8","author":"Geller","year":"2011","journal-title":"Heart Rhythm"},{"key":"2026011921132269500_ejhf185-bib-0016","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/eurheartj\/ehl099","article-title":"Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase]","volume":"27","author":"Cleland","year":"2006","journal-title":"Eur Heart J"},{"key":"2026011921132269500_ejhf185-bib-0017","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.jacc.2010.12.041","article-title":"Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)","volume":"57","author":"Barsheshet","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026011921132269500_ejhf185-bib-0018","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/eurheartj\/ehl505","article-title":"Early and sustained effects of cardiac resynchronization therapy on N-terminal pro-B-type natriuretic peptide in patients with moderate to severe heart failure and cardiac dyssynchrony","volume":"28","author":"Fruhwald","year":"2007","journal-title":"Eur Heart J"},{"key":"2026011921132269500_ejhf185-bib-0019","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/eurheartj\/ehq407","article-title":"Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT","volume":"32","author":"Barsheshet","year":"2011","journal-title":"Eur Heart J"},{"key":"2026011921132269500_ejhf185-bib-0020","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1093\/eurheartj\/ehp359","article-title":"The European cardiac resynchronization therapy survey","volume":"30","author":"Dickstein","year":"2009","journal-title":"Eur Heart J"},{"key":"2026011921132269500_ejhf185-bib-0021","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/eurjhf\/hfr158","article-title":"Scientific Committee, National Coordinators, and Investigators. The European CRT Survey: 1 year (9\u201315 months) follow-up results","volume":"14","author":"Bogale","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2026011921132269500_ejhf185-bib-0022","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0002-9149(83)90394-6","article-title":"Prognosis after myocardial infarction","volume":"52","author":"Moss","year":"1983","journal-title":"Am J Cardiol"},{"key":"2026011921132269500_ejhf185-bib-0023","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.jacc.2012.11.051","article-title":"The influence of left ventricular ejection fraction on the effectiveness of cardiac resynchronization therapy: MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)","volume":"61","author":"Kutyifa","year":"2013","journal-title":"J Am Coll Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejhf.185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/16\/12\/1323\/66433388\/eurjhf_16_12_1323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/16\/12\/1323\/66433388\/eurjhf_16_12_1323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:15:30Z","timestamp":1768875330000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/16\/12\/1323\/8427619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,7]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,11,7]]},"published-print":{"date-parts":[[2014,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.185","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,12]]},"published":{"date-parts":[[2014,11,7]]}}}