{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:26:55Z","timestamp":1793179615360,"version":"4.5.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":2058,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Incorporation of remote monitoring of pulmonary artery pressure and vital signs has been demonstrated to reduce heart failure (HF) hospitalization and all-cause mortality in selected symptomatic HF patients. The aim of this study is to investigate the safety and accuracy of the new CordellaTM Pulmonary Artery Pressure Sensor (Endotronix, Inc., Chicago, IL, USA) and the usability of the comprehensive CordellaTM Heart Failure System (CHFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Multicentre, open-label, first-in-human, feasibility study to evaluate the CHFS and the safety and accuracy of the Cordella\u2122 Pulmonary Artery Pressure Sensor in 15 patients with New York Heart Association class III HF. All patients were successfully implanted with the Cordella Pulmonary Artery Pressure Sensor, without sensor failure. No device system-related complications, defined as invasive treatment, device explant or death, occurred. The primary efficacy endpoint of a mean pulmonary artery pressure at 90\u2009days was met in all but one patients with a cohort difference of 2.7\u2009mmHg (Cordella Sensor 22.5\u2009\u00b1\u200911.8\u2009mmHg, Swan\u2013Ganz catheter 25.2\u2009\u00b1\u20098.5\u2009mmHg). One patient did not go through the 90-day right heart catheterization for safety reasons. Patient adherence to daily measurement, transmission of vital signs and pulmonary artery pressure sensor readings were recorded 99% of the time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The initial experience of the CHFS incorporating comprehensive vital signs and pulmonary artery pressure monitoring enables safe and accurate monitoring of HF status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1870","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T01:57:32Z","timestamp":1590976652000},"page":"1912-1919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Digital Health Care Solution for Proactive Heart Failure Management with the Cordella Heart Failure System: Results of the SIRONA First-in-Human Study"],"prefix":"10.1093","volume":"22","author":[{"given":"Wilfried","family":"Mullens","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Ziekenhuis Oost-Limburg , Genk ,","place":["Belgium"]},{"name":"University Hasselt , Hasselt ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Galway University Hospital, Saolta Group, CURAM and BioInnovate Ireland, National University of Ireland Galway , Galway ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dupont","sequence":"additional","affiliation":[{"name":"University Hasselt , Hasselt ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.K.","family":"Rothman","sequence":"additional","affiliation":[{"name":"University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"The Lambe Institute for Translational Medicine and CURAM, National University of Ireland Galway , Galway ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"2026011721374826300_ejhf1870-bib-0001","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0140-6736(11)60101-3","article-title":"Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial","volume":"377","author":"Abraham","year":"2011","journal-title":"Lancet"},{"key":"2026011721374826300_ejhf1870-bib-0002","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jchf.2015.11.011","article-title":"Interventions linked to decreased heart failure hospitalizations during ambulatory pulmonary artery pressure monitoring","volume":"4","author":"Constanzo","year":"2016","journal-title":"JACC Heart Fail"},{"key":"2026011721374826300_ejhf1870-bib-0003","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0140-6736(18)31880-4","article-title":"Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial","volume":"392","author":"Koehler","year":"2018","journal-title":"Lancet"},{"key":"2026011721374826300_ejhf1870-bib-0004","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ahj.2010.10.041","article-title":"Safety and accuracy of a wireless pulmonary artery pressure monitoring system in patients with heart failure","volume":"161","author":"Abraham","year":"2011","journal-title":"Am Heart J"},{"key":"2026011721374826300_ejhf1870-bib-0005","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/ejhf.1531","article-title":"Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of the Heart Failure Association of the European Society of Cardiology","volume":"21","author":"Seferovic","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2026011721374826300_ejhf1870-bib-0006","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCULATIONAHA.116.026184","article-title":"Impact of practice-based management of pulmonary artery pressures in 2000 patients implanted with the CardioMEMS sensor","volume":"135","author":"Heywood","year":"2017","journal-title":"Circulation"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejhf.1870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.1870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.1870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/22\/10\/1912\/66108349\/eurjhf_22_10_1912.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/22\/10\/1912\/66108349\/eurjhf_22_10_1912.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:40:13Z","timestamp":1768704013000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/22\/10\/1912\/8384556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,31]]},"references-count":6,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,5,31]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ejhf.1870","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,5,31]]},"assertion":[{"value":"2020-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}