{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:33:22Z","timestamp":1790429602856,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Advances in diagnostic imaging have increased the recognition of coexisting transthyretin cardiac amyloidosis (ATTR\u2010CA) and severe aortic stenosis (AS), with a reported prevalence between 8\u201316%. In this prospective study, we aimed to evaluate the implications of ATTR\u2010CA on outcomes after transcatheter aortic valve replacement (TAVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      At two academic centres, we screened patients with severe AS undergoing TAVR for ATTR\u2010CA. Using Kaplan\u2013Meier analysis, we compared survival free from death and a combined endpoint of death and first heart failure hospitalization between patients with and without ATTR\u2010CA. Cox proportional\u2010hazards models were used to determine the association of ATTR\u2010CA with these endpoints. The rate of heart failure hospitalization was compared amongst those with and without ATTR\u2010CA. Overall, 204 patients (83\u2009years, 65% male, Society of Thoracic Surgeons score 6.6%, 72% New York Heart Association class III\/IV) were included, 27 (13%) with ATTR\u2010CA. Over a median follow\u2010up of 2.04\u2009years, there was no difference in mortality (log rank,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.99) or the combined endpoint (log rank,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.79) between patients with and without ATTR\u2010CA. In Cox proportional\u2010hazards models, the presence of ATTR\u2010CA was not associated with death. However, patients with ATTR\u2010CA had increased rates of heart failure hospitalization at 1\u00a0year (0.372 vs. 0.114 events\/person\u2010year,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.004) and 3\u2009years (0.199 vs. 0.111 events\/person\u2010year,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.087) following TAVR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In moderate\u2010risk patients with severe AS undergoing TAVR, there was a 13% prevalence of ATTR\u2010CA, which did not affect mortality. The observed increase in heart failure hospitalization following TAVR in those with ATTR\u2010CA suggests the consequences of the underlying infiltrative myopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.1974","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T03:34:49Z","timestamp":1596080089000},"page":"250-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Unveiling outcomes in coexisting severe aortic stenosis and transthyretin cardiac amyloidosis"],"prefix":"10.1093","volume":"23","author":[{"given":"Hannah","family":"Rosenblum","sequence":"first","affiliation":[{"name":"Center for Cardiac Amyloidosis, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"The Amyloidosis Center, Division of Cardiology Oregon Health &amp; Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Narotsky","sequence":"additional","affiliation":[{"name":"Center for Cardiac Amyloidosis, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Columbia University Mailman School of Public Health  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadira","family":"Hamid","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca T.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel","family":"Kodali","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Vahl","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamim","family":"Nazif","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology Columbia University College 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L.","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research Center Minneapolis Heart Institute Foundation  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Center for Cardiac Amyloidosis, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Center for Cardiac Amyloidosis, Division of Cardiology Columbia University College of Physicians &amp; Surgeons  New York NY USA"},{"name":"Department of Biostatistics Columbia University Mailman School of Public Health  New York NY 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