{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:09:15Z","timestamp":1787864955234,"version":"build-2784847793"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Uniwersytet Medyczny im. Piast\u00f3w Slaskich we Wroclawiu","doi-asserted-by":"publisher","award":["ST.E190.16.067"],"award-info":[{"award-number":["ST.E190.16.067"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Iron deficiency (ID) is frequent in heart failure (HF), linked with exercise intolerance and poor prognosis. Intravenous iron repletion improves clinical status in HF patients with left ventricular ejection fraction (LVEF) \u226445%. However, uncertainty exists about the accuracy of serum biomarkers in diagnosing ID. The aims of this study were (i) to identify the iron biomarker with the greatest accuracy for the diagnosis of ID in bone marrow in patients with ischaemic HF, and (ii) to establish the prevalence of ID using this biomarker and its prognostic value in HF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Bone marrow was stained for iron in 30 patients with ischaemic HF with LVEF \u226445% and 10 healthy controls, and ID was diagnosed for 0\u20131 grades (Gale scale). A total of 791 patients with HF with LVEF \u226445% were prospectively followed up for 3\u2009years. Serum ferritin, transferrin saturation, soluble transferrin receptor (sTfR) were assessed as iron biomarkers. Most patients with HF (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a025, 83%) had ID in bone marrow, but none of the controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Serum sTfR had the best accuracy in predicting ID in bone marrow (area under the curve 0.920, 95% confidence interval 0.761\u20130.987, for cut\u2010off 1.25\u2009mg\/L sensitivity 84%, specificity 100%). Serum sTfR was \u22651.25\u2009mg\/L in 47% of HF patients, in 56% and 46% of anaemics and non\u2010anaemics, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The reclassification methods revealed that serum sTfR significantly added the prognostic value to the baseline prognostic model, and to the greater extent than plasma N\u2010terminal pro B\u2010type natriuretic peptide. Based on internal derivation and validation procedures, serum sTfR \u22651.41\u2009mg\/L was the optimal threshold for predicting 3\u2010year mortality, independent of other established variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High serum sTfR accurately reflects depleted iron stores in bone marrow in patients with HF, and identifies those with a high 3\u2010year mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2036","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T04:13:34Z","timestamp":1603858414000},"page":"919-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["High soluble transferrin receptor in patients with heart failure: a measure of iron deficiency and a strong predictor of mortality"],"prefix":"10.1093","volume":"23","author":[{"given":"Radoslaw","family":"Sierpinski","sequence":"first","affiliation":[{"name":"Medical Research Agency  Warsaw Poland"},{"name":"Collegium Medicum, Cardinal Wyszy\u0144ski University in Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystian","family":"Josiak","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  Wroclaw Poland"},{"name":"Centre for Heart Diseases, University Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Suchocki","sequence":"additional","affiliation":[{"name":"Biostatistics Group, Department of Genetics Wroclaw University of Environmental and Life Sciences  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Wojtas\u2010Polc","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  Wroclaw Poland"},{"name":"Department of Cardiology Military Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Occupational Medicine and Hypertension, Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Butrym","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Occupational Medicine and Hypertension, Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Rozentryt","sequence":"additional","affiliation":[{"name":"Third Department of Cardiology Silesian Center for Heart Disease  Zabrze Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Comin\u2010Colet","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Failure Program, Hospital del Mar  Barcelona Spain"},{"name":"Department of Medicine Autonomous University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Division of Applied Cachexia Research, Department of Cardiology Charit\u00e9 Medical School  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Kosmala","sequence":"additional","affiliation":[{"name":"Centre for Heart Diseases, University Hospital  Wroclaw Poland"},{"name":"Department of Cardiology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Przewlocka\u2010Kosmala","sequence":"additional","affiliation":[{"name":"Centre for Heart Diseases, University Hospital  Wroclaw Poland"},{"name":"Department of Cardiology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Banasiak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Military Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Nowak","sequence":"additional","affiliation":[{"name":"Third Department of Cardiology Silesian Center for Heart Disease  Zabrze Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Applied Cachexia Research, Department of Cardiology Charit\u00e9 Medical School  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hull York Medical School, University of Hull, Castle Hill Hospital  Kingston\u2010upon\u2010Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  Wroclaw Poland"},{"name":"Centre for Heart Diseases, University Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa A.","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  Wroclaw Poland"},{"name":"Centre for Heart Diseases, University Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61235-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.33963\/KP.15089"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq158"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs377"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.040"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi388"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.034"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.960906"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2011.08.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12485"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.01.017"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1434"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr504"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.036"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027497"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12462"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12490"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.823"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.473"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1710"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs224"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01490506"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286260"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.228874"},{"key":"e_1_2_6_28_1","first-page":"345","article-title":"Soluble transferrin receptors and iron deficiency, a step beyond ferritin. A systematic review","volume":"18","author":"Koulaouzidis A","year":"2009","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21279"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.08.006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041809"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104793"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.015834"},{"key":"e_1_2_6_34_1","first-page":"5","article-title":"Nutritional anaemias. Report of a WHO scientific group","volume":"405","author":"WHO Scientific Group on Nutritional Anaemias & World Health Organization","year":"1968","journal-title":"World Health Organ Tech Rep Ser"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00362-008-0156-x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-74075-1"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1923-9"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_2_6_41_1","unstructured":"AkcinHM.Direct Adjustment Method on Aalen's Additive Hazards Model for Competing Risks Data. Thesis Georgia State University;2008."},{"key":"e_1_2_6_42_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development CoreTeam","year":"2013"},{"key":"e_1_2_6_43_1","volume-title":"Williams Hematology","author":"Fairbanks V","year":"2001"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004519"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu235"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2019.0014"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041199"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2015.08.017"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0528"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015480"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010887"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2006.12.003"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.676S"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.568S"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1620"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02829934"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn301"},{"key":"e_1_2_6_58_1","first-page":"2","article-title":"Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases","volume":"2","author":"Kell DB","year":"2009","journal-title":"BMC Med Genet"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq240"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7100175"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9738-4"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12314"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12282"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1154"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"}],"updated-by":[{"DOI":"10.1002\/ejhf.2383","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000}}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2036","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:15:45Z","timestamp":1767701745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ejhf.2036"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2036","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]},"assertion":[{"value":"2020-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}