{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:34:55Z","timestamp":1784327695705,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Many cancer patients die due to cardiovascular disease and sudden death, but data on ventricular arrhythmia prevalence and prognostic importance are not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Between 2005 and 2010, we prospectively enrolled 120 unselected patients with lung, colon, or pancreatic cancer due to one of three diagnoses: colorectal (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200933), pancreatic (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200954), or non\u2010small cell lung cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200933). All were free of manifest cardiovascular disease. They were compared to 43 healthy controls similar in age and sex distribution. Each participant underwent 24\u2009h electrocardiogram recording and cancer patients were followed for up to 12.5\u2009years for survival (median 21\u2009months). Ninety\u2010six cancer patients (80%) died during follow\u2010up [5\u2010year survival: 27% (95% confidence interval 19\u201335%)]. Non\u2010sustained ventricular tachycardia (NSVT) was more frequent in cancer patients vs. controls (8% vs. 0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.021). The number of premature ventricular contractions (PVCs) over 24\u2009h was not increased in cancer patients vs. controls (median 4 vs. 9,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.2). In multivariable analysis, NSVT [hazard ratio (HR) 2.44,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.047] and PVCs (per 100, HR 1.021,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.047) were both significant predictors of mortality, independent of other univariable mortality predictors including tumour stage, cancer type, potassium concentration, prior surgery, prior cardiotoxic chemotherapy, and haemoglobin. In patients with colorectal and pancreatic cancer, \u226550 PVCs\/24\u2009h predicted mortality (HR 2.30,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.0024), and was identified in 18% and 26% of patients, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010sustained ventricular tachycardia is more frequent in unselected patients with colorectal, pancreatic, and non\u2010small cell lung cancer and together with PVCs predict long\u2010term mortality. This raises the prospect of cardiovascular mortality being a target for future treatment interventions in selected cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2059","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T05:07:35Z","timestamp":1606021655000},"page":"145-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Ventricular tachycardia, premature ventricular contractions, and mortality in unselected patients with lung, colon, or pancreatic cancer: a prospective study"],"prefix":"10.1093","volume":"23","author":[{"given":"Markus S.","family":"Anker","sequence":"first","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology (CVK) Charit\u00e9 University Medicine Berlin  Berlin Germany"},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT)  Berlin Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) partner site Berlin  Berlin Germany"},{"name":"Department of Cardiology (CBF) Charit\u00e9 University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of G\u00f6ttingen Medical Center  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Pisana  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Riess","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Charit\u00e9 \u2010 Campus Virchow\u2010Klinikum (CVK)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Eucker","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Benjamin Franklin Campus Charit\u00e9 University of Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Porthun","sequence":"additional","affiliation":[{"name":"Norwegian University of Science and Technology  Campus Gj\u00f8vik (NTNU\u2010Gj\u00f8vik) Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi Medical Center  Jackons MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahir","family":"Karakas","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology University Heart Center Hamburg  Hamburg Germany"},{"name":"Partner Site Hamburg\/Kiel\/L\u00fcbeck German Center for Cardiovascular Research  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Haverkamp","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology (CVK) Charit\u00e9 University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK) partner site Berlin  Berlin Germany"},{"name":"Department of Cardiology (CBF) Charit\u00e9 University Medicine Berlin  Berlin Germany"},{"name":"Berlin Institute of Health (BIH)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology (CVK) Charit\u00e9 University Medicine Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050281"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197402)33:2<568::AID-CNCR2820330236>3.0.CO;2-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23315"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw604"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1252"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1689"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw211"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130926.51766.CC"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.670"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601650113"},{"key":"e_1_2_6_12_1","first-page":"127","article-title":"Definition of terms related to cardiac rhythm. 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