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Two independent cardiologists centrally adjudicated the final diagnosis. Diagnostic accuracy for acute heart failure (AHF) was quantified by the area under the receiver operating characteristic curve (AUC). All\u2010cause mortality within 360\u2009days was the prognostic endpoint. Among 1083 patients eligible for diagnostic analysis, 51% had AHF. cMyC concentrations at presentation were higher among AHF patients vs. patients with other final diagnoses [72 (interquartile range, IQR 39\u2013156) vs. 22\u2009ng\/L (IQR 12\u201342),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001)]. cMyC's AUC was high [0.81, 95% confidence interval (CI) 0.78\u20130.83], higher than hs\u2010cTnT's (0.79, 95% CI 0.76\u20130.82,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u00a00.081) and lower than NT\u2010proBNP's (0.91, 95% CI 0.89\u20130.93,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among 794 AHF patients eligible for prognostic analysis, 28% died within 360\u2009days; cMyC plasma concentrations above the median indicated increased risk of death (hazard ratio 2.19, 95% CI 1.66\u20132.89;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). cMyC's prognostic accuracy was comparable with NT\u2010proBNP's and hs\u2010cTnT's. cMyC did not independently predict all\u2010cause mortality when used in validated multivariable regression models. In novel multivariable regression models including medication, age, left ventricular ejection fraction, and discharge creatinine, cMyC remained an independent predictor of death and had no interactions with medical therapies at discharge.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cardiac myosin\u2010binding protein C may aid physicians in the rapid triage of patients with suspected AHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2094","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T19:51:04Z","timestamp":1610653864000},"page":"716-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiac myosin\u2010binding protein\n                    <scp>C<\/scp>\n                    in the diagnosis and risk stratification of acute heart failure"],"prefix":"10.1093","volume":"23","author":[{"given":"Nikola","family":"Kozhuharov","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital Basel, University of Basel  Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel (CRIB) University Hospital Basel  Basel Switzerland"},{"name":"Institute of Cardiovascular Medicine and Science Liverpool Heart and Chest Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Wussler","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel, University of Basel  Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel (CRIB) University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kaier","sequence":"additional","affiliation":[{"name":"King's College London BHF Centre The Rayne Institute, St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Strebel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel, University of Basel  Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel (CRIB) University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samyut","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel, University of Basel  Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel (CRIB) University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayana","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Basel, University of Basel  Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel (CRIB) University Hospital Basel  Basel 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