{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:28:40Z","timestamp":1789586920679,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DA 1209\/4\u20133"],"award-info":[{"award-number":["DA 1209\/4\u20133"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 3696\/3\u20131"],"award-info":[{"award-number":["ME 3696\/3\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO311"],"award-info":[{"award-number":["KFO311"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Coronavirus disease 2019 (COVID\u201019) is a still growing pandemic, causing many deaths and socio\u2010economic damage. Elevated expression of the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) entry receptor angiotensin\u2010converting enzyme 2 on cardiac cells of patients with heart diseases may be related to cardiovascular burden. We have thus analysed cardiovascular and inflammatory microRNAs (miRs), sensitive markers of cardiovascular damage, in critically ill, ventilated patients with COVID\u201019 or influenza\u2010associated acute respiratory distress syndrome (Influenza\u2010ARDS) admitted to the intensive care unit and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Circulating miRs (miR\u201021, miR\u2010126, miR\u2010155, miR\u2010208a, and miR\u2010499) were analysed in a discovery cohort consisting of patients with mechanically\u2010ventilated COVID\u201019 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018) and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015). A validation study was performed in an independent cohort of mechanically\u2010ventilated COVID\u201019 patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020), Influenza\u2010ARDS patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013) and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032). In both cohorts, RNA was isolated from serum and cardiovascular disease\/inflammatory\u2010relevant miR concentrations were measured by miR\u2010specific TaqMan PCR analyses. In both the discovery and the validation cohort, serum concentration of miR\u201021, miR\u2010155, miR\u2010208a and miR\u2010499 were significantly increased in COVID\u201019 patients compared to healthy controls. Calculating the area under the curve using receiver operating characteristic analysis miR\u2010155, miR\u2010208a and miR\u2010499 showed a clear distinction between COVID\u201019 and Influenza\u2010ARDS patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory study, inflammation and cardiac myocyte\u2010specific miRs were upregulated in critically ill COVID\u201019 patients. Importantly, miR profiles were able to differentiate between severely ill, mechanically\u2010ventilated Influenza\u2010ARDS and COVID\u201019 patients, indicating a rather specific response and cardiac involvement of COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2096","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T19:54:15Z","timestamp":1610654055000},"page":"468-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Circulating cardiovascular\n                    <scp>microRNAs<\/scp>\n                    in\u00a0critically ill\n                    <scp>COVID<\/scp>\n                    \u201019 patients"],"prefix":"10.1093","volume":"23","author":[{"given":"Ankita","family":"Garg","sequence":"first","affiliation":[{"name":"Institute of Molecular and Translational Therapeutic Strategies (IMTTS) Hannover Medical School  Hannover 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