{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:50:24Z","timestamp":1768931424996,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Duchenne muscular dystrophy (DMD), an inherited X-linked muscular disease, is associated with dilated cardiomyopathy that is responsible for death in 40% of patients. Our objective was to determine whether inotropic reserve is predictive of LV trend over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 69 DMD patients (age 12.2 \u00b1 2.3 years) were investigated. At baseline, LVEF and the presence of inotropic reserve (defined as an increase in LVEF &amp;gt;10% during dobutamine infusion) were investigated using radionuclide ventriculography. During follow-up (FU), LVEF was remeasured after a mean 29 \u00b1 19 months delay. In the whole population, mean LVEF was 58 \u00b1 8% at baseline and declined to 54 \u00b1 11% during FU (P = 0.004). At baseline, 21 patients (30.4%) had LVEF &amp;lt;55% and 38 had no LV inotropic reserve. LVEF declined in the 38 patients (55.1%) without LV inotropic reserve (58 \u00b1 8% to 52 \u00b1 10%, P = 0.001), and not in the other patients (58 \u00b1 8% to 57 \u00b1 11%, P = 0.516) (P = 0.042 for trends in LVEF between groups after adjustment for age, FU duration, and baseline LVEF). Fewer patients with vs. without inotropropic reserve at baseline show a depressed LVEF &amp;lt;55% during follow-up (35.5% vs. 63.2%, respectively, P = 0.030). Similar findings were observed in the subgroups of patients with LVEF &amp;gt;45% or 55% at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inotropic reserve assessment allows the distinction of DMD patients who will vs. those who will not show a deterioration in LVEF, thus offering a sensitive approach for delineating the presence and progression of cardiovascular disease in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.213","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T04:20:02Z","timestamp":1419913202000},"page":"177-181","source":"Crossref","is-referenced-by-count":2,"title":["Reduced Inotropic Reserve is Predictive of Further Degradation in Left Ventricular Ejection Fraction in Patients with Duchenne Muscular Dystrophy"],"prefix":"10.1093","volume":"17","author":[{"given":"Fran\u00e7ois-Xavier","family":"Goudot","sequence":"first","affiliation":[{"name":"Paris 13 University, Avicenne Hospital, Department of Cardiology , APHP, Bobigny ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Wahbi","sequence":"additional","affiliation":[{"name":"Paris Descartes University, APHP, Department of Cardiology, Cochin Hospital , Paris ,","place":["France"]},{"name":"Myology Institute, APHP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"A\u00efssou","sequence":"additional","affiliation":[{"name":"Paris 13 University, Avicenne Hospital, Department of Cardiology , APHP, Bobigny ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Sorbets","sequence":"additional","affiliation":[{"name":"Paris 13 University, Avicenne Hospital, Department of Cardiology , APHP, Bobigny ,","place":["France"]},{"name":"Department of Cardiology, Bichat Hospital , APHP, Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Siam-Tsieu","sequence":"additional","affiliation":[{"name":"Paris Descartes University, APHP, Department of Cardiology, Cochin Hospital , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Eymard","sequence":"additional","affiliation":[{"name":"Myology Institute, APHP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Themar Noel","sequence":"additional","affiliation":[{"name":"Myology Institute, APHP, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris 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