{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:59:29Z","timestamp":1775015969305,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,7]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n Nitroxyl provokes vasodilatation and inotropic and lusitropic effects in animals via post\u2010translational modification of thiols. We aimed to compare effects of the nitroxyl donor cimlanod (BMS\u2010986231) with those of nitroglycerin (NTG) or placebo on cardiac function in patients with chronic heart failure with reduced ejection fraction (HFrEF).<\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n In a randomized, multicentre, double\u2010blind, crossover trial, 45 patients with stable HFrEF were given a 5\u2009h intravenous infusion of cimlanod, NTG, or placebo on separate days. Echocardiograms were done at the start and end of each infusion period and read in a core laboratory. The primary endpoint was stroke volume index derived from the left ventricular outflow tract at the end of each infusion period. Stroke volume index with placebo was 30\u2009\u00b1\u20097\u00a0mL\/m\n 2<\/jats:sup>\n and was lower with cimlanod (29\u2009\u00b1\u20099\u00a0mL\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n \u00a0=\u00a00.03) and NTG (28\u2009\u00b1\u20098\u00a0mL\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n \u00a0=\u00a00.02). Transmitral E\u2010wave Doppler velocity on cimlanod or NTG was lower than on placebo and, consequently, E\/e\u2032 (\n P<\/jats:italic>\n \u00a0=\u00a00.006) and E\/A ratio (\n P<\/jats:italic>\n \u00a0=\u00a00.003) were also lower. NTG had similar effects to cimlanod on these measurements. Blood pressure reduction was similar with cimlanod and NTG and greater than with placebo.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In patients with chronic HFrEF, the haemodynamic effects of cimlanod and NTG are similar. The effects of cimlanod may be explained by venodilatation and preload reduction without additional inotropic or lusitropic effects. Ongoing trials of cimlanod will further define its potential role in the treatment of heart failure.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ejhf.2138","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T07:11:44Z","timestamp":1614064304000},"page":"1147-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Haemodynamic effects of the nitroxyl donor cimlanod (\n BMS<\/scp>\n \u2010986231) in chronic heart failure: a randomized trial"],"prefix":"10.1093","volume":"23","author":[{"given":"Ninian N.","family":"Lang","sequence":"first","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular & Medical Sciences, University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faheem A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular & Medical Sciences, University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Cleland","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics & Clinical Trials University of Glasgow Glasgow UK"},{"name":"National Heart & Lung Institute Royal Brompton & Harefield Hospitals, Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Inova Heart & Vascular Institute Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Teerlink","sequence":"additional","affiliation":[{"name":"Department of Cardiology San Francisco Veterans Affairs Medical Center and School of Medicine, University of California, San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorg","family":"Taubel","sequence":"additional","affiliation":[{"name":"Richmond Pharmacology Limited London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke R.","family":"Hodes","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Anwar","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Science University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Karra","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke Advanced Heart and Lung Failure Clinic, Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Hospital Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nippon Medical School Kawasaki\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxy","family":"Senior","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research Northwick Park Hospital & Department of Cardiology, Royal Brompton Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Khemka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayana G.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"DeSouza","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Princeton NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Seiffert","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Princeton NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Y.","family":"Ye","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Princeton NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Bristol\u2010Myers Squibb Princeton NJ 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Michael","family":"Felker","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke Clinical Research Institute (DCRI), Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.V.","family":"McMurray","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular & Medical Sciences, University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.12.1541"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1557"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.11.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.129254"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201812208"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.188441"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2741\/e118"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3859"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0937302100"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04285"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1504"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.897"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2007.10.004"},{"key":"e_1_2_6_17_1","first-page":"61","article-title":"Effects of intravenous nitroglycerin on hemodynamics and ischemic injury in patients with acute myocardial infarction","volume":"8","author":"Bussmann WD","year":"1978","journal-title":"Eur J Cardiol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.027"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90939-X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(75)90075-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000259328.04159.90"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00630.2012"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:14:52Z","timestamp":1767701692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,9]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/ejhf.2138"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2138","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,9]]},"assertion":[{"value":"2020-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}