{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:30:24Z","timestamp":1790778624600,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To study loop diuretic response and effect of loop diuretic omission in ambulatory heart failure (HF) patients on chronic low\u2010dose loop diuretics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Urine collections were performed on two consecutive days in 40 ambulatory HF patients with 40\u201380\u2009mg furosemide (day 1 with loop diuretic; day 2 without loop diuretic). Three phases were collected each day: (i) first 6\u00a0h; (ii) rest of the day; and (iii) night. On the day of loop diuretic intake, the total natriuresis was 125.9 (86.9\u2013155.0) mmol\/24\u2009h and urine output was 1650 (1380\u20132025) mL\/24\u2009h. There was a clear loop diuretic response with a natriuresis of 9.4 (6.7\u201315.9) mmol\/h and a urine output of 117 (83\u2013167) mL\/h during the first 6\u00a0h, followed by a significant drop in natriuresis and urine output during the rest of the day [2.6 (1.8\u20134.8) mmol\/h and 55 (33\u201371) mL\/h] and night [2.2 (1.6\u20133.5) mmol\/h and 44 (34\u201373) mL\/h]. On day 2, after loop diuretic omission, the natriuresis and urine output remained similarly low the entire day, resulting in a 50% reduction in natriuresis [55.1 (33.5\u201377.7) mmol\/24\u2009h;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001] and a 31% reduction in urine output [1035 (875\u20131425) mL\/24\u2009h;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001] compared with the day of loop diuretic intake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with HF on chronic loop diuretic treatment still have a clear diuretic response phase, while loop diuretic omission leads to a significant drop in natriuresis and urine output, arguing against routine cessation of low\u2010dose loop diuretics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2145","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T05:15:27Z","timestamp":1614489327000},"page":"1110-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diuretic response and effects of diuretic omission in ambulatory heart failure patients on chronic low\u2010dose loop diuretic therapy"],"prefix":"10.1093","volume":"23","author":[{"given":"Jeroen","family":"Dauw","sequence":"first","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk Belgium"},{"name":"UHasselt\u00a0\u2013\u00a0Hasselt University, Doctoral School for Medicine and Life Sciences, LCRC  Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk 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