{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:01:50Z","timestamp":1782464510313,"version":"3.54.5"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The Italian Society of Interventional Cardiology (GIse) registry Of Transcatheter treatment of mitral valve regurgitaTiOn (GIOTTO) was conceived in order to assess the safety and efficacy of MitraClip therapy in Italy. The aim of this study was to assess procedural and mid\u2010term outcomes, and clinical and echocardiographic predictors of mid\u2010term mortality after MitraClip therapy, stratifying the results according to the diagnosis of functional and degenerative mitral regurgitation (FMR vs. DMR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Between January 2016 and March 2020, 1659 patients were prospectively included in the GIOTTO registry (FMR 59.4% vs. DMR 40.6%). Acute Mitral Valve Academic Research Consortium (MVARC) technical success was achieved in 97.2% of patients, without differences between FMR and DMR and with sustained results at 30\u2009days. In the study population, all\u2010cause mortality was 4.0%, 17.5% and 34.6% at 30\u2009days, 1\u2009year and 2\u2009years, respectively. Cardiovascular death was the most frequent cause of mortality. Overall hospitalization rates were 6.3%, 23.4% and 31.7% at 30\u2009days, 1\u2009year and 2\u2009years, respectively. The most frequent cause of hospitalization was heart failure, particularly in the first 30\u2009days. FMR and MVARC structural and functional failure were strongly associated with 1\u2010year mortality. Residual mitral regurgitation 1+\u2009(rMR) was independently related to a reduced risk of 1\u2010year mortality (hazard ratio 0.62;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005). Coherently, at 2\u2010year follow up, FMR was associated with worse outcomes than DMR, and Kaplan\u2013Meier all\u2010cause mortality was related to rMR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Functional mitral regurgitation aetiology affects 1\u2010year mortality after MitraClip implantation, and differences in mortality and hospitalization rates between FMR and DMR can be observed within 2\u2009years. Optimal rMR 1+ was correlated to a more favourable mid\u2010term outcome, particularly in FMR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2159","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T06:50:04Z","timestamp":1616223004000},"page":"1364-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Italian Society of Interventional Cardiology (\n                    <scp>GIse<\/scp>\n                    ) registry Of Transcatheter treatment of mitral valve r\n                    <scp>egurgitaTiOn<\/scp>\n                    (\n                    <scp>GIOTTO<\/scp>\n                    ): impact of valve disease aetiology and residual mitral regurgitation after\n                    <scp>MitraClip<\/scp>\n                    implantation"],"prefix":"10.1093","volume":"23","author":[{"given":"Francesco","family":"Bedogni","sequence":"first","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato  San Donato Milanese, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Popolo Rubbio","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato  San Donato Milanese, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Grasso","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Centro Alte Specialit\u00e0 e Trapianti (CAST) Azienda Ospedaliero\u2010Universitaria Policlinico\u2010Vittorio Emanuele, University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department Spedali Civili Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department San Raffaele University Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Giordano","sequence":"additional","affiliation":[{"name":"Invasive Cardiology Unit Pineta Grande Hospital  Castel Volturno Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Tusa","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato  San Donato Milanese, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato  San Donato Milanese, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Policlinico San Donato  San Donato Milanese, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L.","family":"Bartorelli","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Cardio\u2010Thoracic\u2010Vascular Department San Raffaele University Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmo","family":"Godino","sequence":"additional","affiliation":[{"name":"Cardio\u2010Thoracic\u2010Vascular Department San Raffaele University Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Citro","sequence":"additional","affiliation":[{"name":"University Hospital San Giovanni di Dio e Ruggi d'Aragona  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De Felice","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. 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