{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:18:42Z","timestamp":1773803922238,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The number of transcatheter mitral valve repair (TMVr) procedures has increased substantially during the last years. A better understanding of the relationship between hospital volume of transcatheter transvenous mitral valve repairs using MitraClip\u00ae and patient outcomes may provide information for future policy decisions to improve patient management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We analysed patient characteristics and in\u2010hospital outcomes for all TMVr procedures using MitraClip\u00ae performed in Germany from 2011 to 2017. Hospitals were stratified according to centre volumes and patients were compared for baseline characteristics and adverse in\u2010hospital events. Overall, 24\u2009709 inpatients were treated during the observational period. Patients treated in centres with a volume of \u226410 procedures annually developed more often pulmonary embolism (odds ratio 2.22, 95% confidence interval 1.19\u20134.13;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.012) compared to those treated in centres with a volume of &gt;10 procedures annually, whereas no association of centre volume (\u226410 or &gt;10) was found with in\u2010hospital mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.728). Although patients treated in centres with an annual volume &gt;25 TMVr procedures had higher numbers of comorbidities compared to those treated in centres with an annual volume of \u226425 TMVr procedures, in\u2010hospital mortality did not differ (3.6% vs. 3.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.485). Similarly, when centre volumes were stratified for \u226450 vs. &gt;50 procedural volumes, no association with in\u2010hospital mortality was recorded (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.792). A lower rate of mitral valve surgery after MitraClip\u00ae was observed over time, particularly in high\u2010volume centres.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Annual numbers of MitraClip\u00ae implantations increased from 2011 to 2017 in Germany, whereas in\u2010hospital mortality remained stable. Although patients treated in high\u2010volume centres had a more unfavourable risk profile, in\u2010hospital mortality was comparable to that of low\u2010volume centres.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2162","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T02:26:58Z","timestamp":1616552818000},"page":"1380-1389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Centre procedural volume and adverse in\u2010hospital outcomes in patients undergoing percutaneous transvenous edge\u2010to\u2010edge mitral valve repair using\n                    <scp>MitraClip<\/scp>\n                    \u00ae in\n                    <scp>Germany<\/scp>"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0820-9584","authenticated-orcid":false,"given":"Karsten","family":"Keller","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiology I University Medical Center Mainz  Mainz Germany"},{"name":"Center for Thrombosis and Hemostasis (CTH) University Medical Center Mainz  Mainz Germany"},{"name":"Medical Clinic VII, Department of Sports Medicine University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I University Medical Center Mainz  Mainz Germany"},{"name":"Center for Thrombosis and Hemostasis (CTH) University Medical Center Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Schmidtmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center Mainz (Johannes Gutenberg\u2010University Mainz)  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I University Medical Center Mainz  Mainz Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I University Medical Center Mainz  Mainz 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