{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:43:49Z","timestamp":1784641429874,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Patients surviving an acute myocardial infarction (AMI) are at risk of developing symptomatic heart failure (HF) or premature death. We hypothesized that sacubitril\/valsartan, effective in the treatment of chronic HF, prevents development of HF and reduces cardiovascular death following high\u2010risk AMI compared to a proven angiotensin\u2010converting enzyme (ACE) inhibitor. This paper describes the study design and baseline characteristics of patients enrolled in the Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction (PARADISE\u2010MI) trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      PARADISE\u2010MI, a multinational (41 countries), double\u2010blind, active\u2010controlled trial, randomized patients within 0.5\u20137\u2009days of presentation with index AMI to sacubitril\/valsartan or ramipril. Transient pulmonary congestion and\/or left ventricular ejection fraction (LVEF) \u226440% and at least one additional factor augmenting risk of HF or death (age \u226570\u2009years, estimated glomerular filtration rate &lt;60\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , diabetes, prior myocardial infarction, atrial fibrillation, LVEF &lt;30%, Killip class \u2265III, ST\u2010elevation myocardial infarction without reperfusion) were required for inclusion. PARADISE\u2010MI was event\u2010driven targeting 708 primary endpoints (cardiovascular death, HF hospitalization or outpatient development of HF). Randomization of 5669 patients occurred 4.3\u2009\u00b1\u20091.8\u2009days from presentation with index AMI. The mean age was 64\u2009\u00b1\u200912\u2009years, 24% were women. The majority (76%) qualified with ST\u2010segment elevation myocardial infarction; acute percutaneous coronary intervention was performed in 88% and thrombolysis in 6%. LVEF was 37\u2009\u00b1\u20099% and 58% were in Killip class \u2265II.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Baseline therapies in PARADISE\u2010MI reflect advances in contemporary evidence\u2010based care. With enrollment complete PARADISE\u2010MI is poised to determine whether sacubitril\/valsartan is more effective than a proven ACE inhibitor in preventing development of HF and cardiovascular death following AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2191","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T23:11:05Z","timestamp":1618269065000},"page":"1040-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction (PARADISE\u2010MI): design and baseline characteristics"],"prefix":"10.1093","volume":"23","author":[{"given":"Karola S.","family":"Jering","sequence":"first","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital, and Harvard Medical School  Boston MA 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Cardiovascular Medicine Stanford University School of Medicine, Stanford University  Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo P.","family":"Maggioni","sequence":"additional","affiliation":[{"name":"ANMCO Research Center  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Mann","sequence":"additional","affiliation":[{"name":"Washington University Medical Center  St Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.V.","family":"McMurray","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Research Centre University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Lucien","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute University of Montreal  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott 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