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Stratification of patients with ATTR\u2010CM is critical for optimal management and treatment; however, monitoring disease progression is challenging and currently lacks best\u2010practice guidance. In this report, experts with experience in treating amyloidosis and ATTR\u2010CM developed consensus recommendations for monitoring the course of patients with ATTR\u2010CM and proposed meaningful thresholds and frequency for specific parameters. A set of 11 measurable features across three separate domains were evaluated: (i) clinical and functional endpoints, (ii) biomarkers and laboratory markers, and (iii) imaging and electrocardiographic parameters. Experts recommended that one marker from each of the three domains provides the minimum requirements for assessing disease progression. Assessment of cardiac disease status should be part of a multiparametric evaluation in which progression, stability or improvement of other involved systems in transthyretin amyloidosis should also be considered. 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