{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:57:28Z","timestamp":1780099048318,"version":"3.54.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>African\u2010American carriers of the transthyretin (TTR) valine\u2010to\u2010isoleucine substitution (V122I) are at increased risk of heart failure, yet many have relatively subtle abnormalities of left ventricular (LV) function. We sought to explore the influence of this mutation on left atrial (LA) structure and function in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We assessed 1225 genotyped African\u2010Americans (age range, 67\u201389\u2009years) participating in the Atherosclerosis Risk in Communities study who underwent echocardiography and were in sinus rhythm at study Visit 5 (2011 to 2013). Six LA parameters [LA maximum\/minimum volume index, ejection fraction, and LA reservoir, conduit, and contractile longitudinal strains (LS)] were compared between V122I TTR variant carriers (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a046) and non\u2010carriers (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01179). LA minimum volume index was significantly greater and LA contractile LS was worse in carriers than non\u2010carriers (19.5\u2009\u00b1\u200910.6\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      vs. 16.3\u2009\u00b1\u20098.4\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 15.0\u2009\u00b1\u20095.8% vs. 16.8\u2009\u00b1\u20095.7%, respectively, both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Carriers had a significantly higher number of LA abnormalities than non\u2010carriers (1.8\u2009\u00b1\u20092.2 vs. 1.1\u2009\u00b1\u20091.6,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.009). The number of subjects with at least four LA abnormalities was significantly increased among carriers compared with non\u2010carriers (27% vs. 12%; odds ratio 2.43; 95% confidence interval 1.06\u20135.58 after adjusting for age, sex, body mass index, and LV wall thickness and global LS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Left atrial enlargement and dysfunction were common in V122I TTR carriers with sinus rhythm than non\u2010carriers, suggesting that abnormalities of LA function may represent early markers of subclinical disease in these individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2200","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T03:23:52Z","timestamp":1619753032000},"page":"1290-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Left atrial structure and function of the amyloidogenic\n                    <scp>V122I<\/scp>\n                    transthyretin variant in\u00a0elderly African Americans"],"prefix":"10.1093","volume":"23","author":[{"given":"Masatoshi","family":"Minamisawa","sequence":"first","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"},{"name":"Department of Cardiovascular Medicine Shinshu University Hospital, Matsumoto  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo M.","family":"Inciardi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"},{"name":"Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.M.","family":"Cuddy","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candida C.","family":"Quarta","sequence":"additional","affiliation":[{"name":"Alexion Pharmaceuticals, Hayes  Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amil M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Dorbala","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney H.","family":"Falk","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School Public Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine  Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404852"},{"key":"e_1_2_6_5_1","first-page":"1128","article-title":"Left atrial structure and function in cardiac amyloidosis","volume":"18","author":"Nochioka K","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000736"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey042"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey018"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa043"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023361"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2018.1430027"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:14:54Z","timestamp":1767701694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/ejhf.2200"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2200","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"2020-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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