{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:47Z","timestamp":1786977647693,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:00:00Z","timestamp":1625961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2014\/13\/B\/NZ5\/03146"],"award-info":[{"award-number":["2014\/13\/B\/NZ5\/03146"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Abnormal endogenous erythropoietin (EPO) constitutes an important cause of anaemia in chronic diseases. We analysed the relationships between iron deficiency (ID) and the adequacy of endogenous EPO in anaemic heart failure (HF) patients, and the impact of abnormal EPO on 12\u2010month mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We investigated 435 anaemic HF patients (age: 74\u2009\u00b1\u200910\u2009years; males: 60%; New York Heart Association class I or II: 39%; left ventricular ejection fraction: 43\u2009\u00b1\u200917%). Patients with EPO higher than expected for a given haemoglobin were considered EPO\u2010resistant whereas those with EPO lower than expected \u2010 EPO\u2010deficient. ID was defined as serum ferritin &lt;100\u2009\u00b5g\/L or 100\u2013299\u2009\u00b5g\/L with transferrin saturation &lt;20%. EPO\u2010resistant patients (22%) had more advanced HF whereas those with EPO deficiency (57%) were more frequently females and had worse renal function. Lower serum ferritin (indicating depleted body iron stores) was related to higher EPO observed\/predicted ratio when adjusted for significant clinical confounders, including C\u2010reactive protein. One year all\u2010cause mortality was 28% in patients with EPO resistance compared to 17% in patients with EPO deficiency and 10% in patients with adequate EPO (log\u2010rank test for the comparison EPO resistance vs. adequate EPO:\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02). When adjusted for other prognosticators, there was still a trend towards increased 12\u2010month mortality in patients with higher EPO level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anaemic HF patients with endogenous EPO deficiency vs. resistance have different clinical and laboratory characteristics. In such patients, ID contributes to EPO resistance independently of inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2253","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T09:28:24Z","timestamp":1622280504000},"page":"1677-1686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Iron deficiency contributes to resistance to endogenous erythropoietin in anaemic heart failure patients"],"prefix":"10.1093","volume":"23","author":[{"given":"Micha\u0142","family":"Tkaczyszyn","sequence":"first","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  Wroclaw Poland"},{"name":"Centre for Heart Diseases University Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Com\u00edn\u2010Colet","sequence":"additional","affiliation":[{"name":"Bio\u2010Heart Cardiovascular Diseases Research Group Bellvitge Biomedical Research Institute (IDIBELL)  L'Hospitalet de Llobregat, Barcelona Spain"},{"name":"Community Heart Failure Program Cardiology Department, University Hospital Bellvitge, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Enjuanes","sequence":"additional","affiliation":[{"name":"Bio\u2010Heart Cardiovascular Diseases Research Group Bellvitge Biomedical Research Institute (IDIBELL)  L'Hospitalet de Llobregat, Barcelona Spain"},{"name":"Community Heart Failure Program Cardiology Department, University Hospital Bellvitge, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Moliner","sequence":"additional","affiliation":[{"name":"Bio\u2010Heart Cardiovascular Diseases Research Group Bellvitge Biomedical Research Institute (IDIBELL)  L'Hospitalet de Llobregat, Barcelona Spain"},{"name":"Community Heart Failure Program Cardiology Department, University Hospital Bellvitge, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Drozd","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  Wroclaw Poland"},{"name":"Centre for Heart Diseases University Hospital  Wroclaw 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