{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:02:15Z","timestamp":1791925335568,"version":"4.3.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Iron deficiency (ID) is associated with poor prognosis regardless of anaemia. Intravenous iron improves quality of life and outcomes in patients with ID and heart failure (HF) with reduced ejection fraction (HFrEF). In the Swedish HF registry, we assessed (i) frequency and predictors of ID testing; (ii) prevalence and outcomes of ID with\/without anaemia; (iii) use of ferric carboxymaltose (FCM) and its predictors in patients with ID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We used multivariable logistic regressions to assess patient characteristics independently associated with ID testing\/FCM use, and Cox regressions to assess risk of outcomes associated with ID. Of 21\u2009496 patients with HF and any ejection fraction enrolled in 2017\u20132018, ID testing was performed in 27%. Of these, 49% had ID and more specifically 36% had ID\u2212\/anaemia\u2212, 15% ID\u2212\/anaemia+, 29% ID+\/anaemia\u2212, and 20% ID+\/anaemia+ (48%, 39%, 13%, 30% and 18% in HFrEF, respectively). Risk of recurrent all\u2010cause hospitalizations was higher in patients with ID regardless of anaemia. Of 1959 patients with ID, 19% received FCM (24% in HFrEF). Important independent predictors of ID testing and FCM use were anaemia, higher New York Heart Association class, having HFrEF, and referral to HF specialty care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide HF registry, ID testing occurred in only about a quarter of the patients. Among tested patients, ID was present in one half, but only one in five patients received FCM indicating low adherence to current guidelines on screening and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2338","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T04:36:45Z","timestamp":1630643805000},"page":"1844-1854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Phenotyping heart failure patients for iron deficiency and use of intravenous iron therapy: data from the\n                    <scp>S<\/scp>\n                    wedish\n                    <scp>H<\/scp>\n                    eart\n                    <scp>F<\/scp>\n                    ailure\n                    <scp>R<\/scp>\n                    egistry"],"prefix":"10.1093","volume":"23","author":[{"given":"Peter Moritz","family":"Becher","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Cardiology University Heart and Vascular Center Hamburg  Hamburg Germany"},{"name":"German Center of Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Schrage","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Cardiology University Heart and Vascular Center Hamburg  Hamburg Germany"},{"name":"German Center of Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/L\u00fcbeck  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Benson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke University Medical Center  Durham NC USA"},{"name":"Duke Clinical Research Institute  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin","family":"Corovic Cabrera","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education Karolinska Institutet, S\u00f6dersjukhuset  Stockholm Sweden"},{"name":"Department of Cardiology S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Dahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Department of Health, Medicine and Caring Sciences Linkoping University  Linkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe M.C.","family":"Rosano","sequence":"additional","affiliation":[{"name":"Centre for Clinical and Basic Research, Department of Cardiac &amp; Pulmonary Rehabilitation Sciences, IRCCS San Raffaele Pisana  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa A.","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University, and Centre for Heart Diseases, University Hospital  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK); and Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site Berlin; Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Heart and Vascular Theme Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Savarese","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Heart and Vascular Theme Karolinska University Hospital  Stockholm 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