{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:50:37Z","timestamp":1780120237830,"version":"3.54.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sympathetic overactivity, which predicts poor outcome in patients with heart failure, normalizes following cardiac transplantation. We tested the hypothesis that haemodynamic improvement following left ventricular assist device (LVAD) implantation is also associated with reductions in centrally generated sympathetic activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      In eight patients with heart failure (two women, six men, age 44\u201366\u2009years), we continuously recorded electrocardiogram, beat\u2010to\u2010beat finger blood pressure, respiration, and muscle sympathetic nerve activity (MSNA) before and after implantation of the continuous\u2010flow LVAD devices HeartWare HVAD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20094) and HeartMate II (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20092), and the non\u2010continuous\u2010flow device HeartMate 3 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20092). LVAD implantation increased cardiac output by 1.29\u2009\u00b1\u20090.88\u2009L\/min (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.060) and mean arterial pressure by 16.2\u00a0\u00b1\u20097.9\u2009mmHg (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.001), while reducing pulse pressure by 25.3\u00a0\u00b1\u20099.8\u2009mmHg (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.001). LVAD implantation did not change MSNA burst frequency (\u22121.3\u00a0\u00b1\u20097.5 bursts\/min,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.636), total activity (+0.62\u2009\u00b1\u20091.83 au,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.369), or normalized activity (+0.63\u2009\u00b1\u20094.23,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.685). MSNA burst incidence was decreased (\u22127.8\u00a0\u00b1\u20099.3 bursts\/100 heart beats,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.049). However, cardiac ectopy altered MSNA bursting patterns that could be mistaken for sympatholysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implantation of current design LVAD does not consistently normalize sympathetic activity in patients with end\u2010stage heart failure despite haemodynamic improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2344","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T08:40:41Z","timestamp":1631090441000},"page":"1955-1959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sympathetic vasoconstrictor activity before and after left ventricular assist device implantation in patients with end\u2010stage heart failure"],"prefix":"10.1093","volume":"23","author":[{"given":"Karsten","family":"Heusser","sequence":"first","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wittkoepper","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bara","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Haverich","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Diedrich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center Vanderbilt University Medical Center &amp; Department of Biomedical Engineering, Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Levine","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital  Dallas TX USA"},{"name":"Department of Internal Medicine, Division of Cardiology University of Texas Southwestern Medical Center  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan D.","family":"Schmitto","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Jordan","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center  Cologne Germany"},{"name":"Chair of Aerospace Medicine University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Tank","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine German Aerospace Center  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.03.056"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409273111303"},{"key":"e_1_2_6_4_1","first-page":"516","article-title":"Normalization of total body and regional sympathetic hyperactivity in heart failure after heart 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