{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:00:29Z","timestamp":1782828029169,"version":"3.54.5"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hospitalization for acute heart failure (HF) is followed by a vulnerable time with increased risk of readmission or death, thus requiring particular attention after discharge. In this study, we examined the impact of intensive, early follow\u2010up among patients at high readmission risk at discharge after treatment for acute HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Hospitalized acute HF patients were included with at least one of the following: previous acute HF\u2009&lt;\u20096\u2009months, systolic blood pressure\u2009\u2264\u2009110\u2009mmHg, creatininaemia\u2009\u2265\u2009180\u2009\u00b5mol\/L, or B\u2010type natriuretic peptide\u2009\u2265\u2009350\u2009pg\/mL or N\u2010terminal pro B\u2010type natriuretic peptide\u2009\u2265\u20092200\u2009pg\/mL. Patients were randomized to either optimized care and education with serial consultations with HF specialist and dietician during the first 2\u20133\u2009weeks, or to standard post\u2010discharge care according to guidelines. The primary endpoint was all\u2010cause death or first unplanned hospitalization during 6\u2010month follow\u2010up. Among 482 randomized patients (median age 77 and median left ventricular ejection fraction 35%), 224 were hospitalized or died. In the intensive group, loop diuretics (46%), beta\u2010blockers (49%), angiotensin\u2010converting enzyme inhibitors or angiotensin receptor blockers (39%) and mineralocorticoid receptor antagonists (47%) were titrated. No difference was observed between groups for the primary endpoint (hazard ratio 0.97; 95% confidence interval 0.74\u20131.26), nor for mortality at 6 or 12\u2009months or unplanned HF rehospitalization. Additionally, no difference between groups according to age, previous HF and left ventricular ejection fraction was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In high\u2010risk HF, intensive follow\u2010up early post\u2010discharge did not improve outcomes. This vulnerable post\u2010discharge time requires further studies to clarify useful transitional care services.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2357","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T13:14:01Z","timestamp":1633871641000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Early and short\u2010term intensive management after discharge for patients hospitalized with acute heart failure: a randomized study (\n                    <scp>ECAD\u2010HF<\/scp>\n                    )"],"prefix":"10.1093","volume":"24","author":[{"given":"Damien","family":"Logeart","sequence":"first","affiliation":[{"name":"H\u00f4pital Lariboisi\u00e8re Fernand Widal, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmannuelle","family":"Berthelot","sequence":"additional","affiliation":[{"name":"H\u00f4pital Kremlin Bic\u00eatre, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bihry","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Joseph et Saint Luc  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Eschalier","sequence":"additional","affiliation":[{"name":"H\u00f4pital Gabriel\u2010Montpied  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Salvat","sequence":"additional","affiliation":[{"name":"H\u00f4pital Michallon  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Garcon","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Joseph  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Eicher","sequence":"additional","affiliation":[{"name":"H\u00f4pital F. 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