{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:55:23Z","timestamp":1792184123536,"version":"4.4.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the feasibility and efficacy of interatrial shunt devices (IASD) for the treatment of chronic heart failure (CHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      MEDLINE and the Cochrane Central Register of Controlled Trials from inception until April 2021 were searched for prospective studies investigating dedicated transcatheter IASD for the treatment of CHF. Standardised mean differences were calculated for the within\u2010group changes before and after implantation of the IASD. The pre\u2010defined primary outcome was change in 6\u2010min walking distance (6MWD) from baseline to 12\u2009months. Other outcomes were change in New York Heart Association class, health\u2010related quality of life (HRQoL), echocardiographic and haemodynamic data, device performance and safety. Subgroup analyses were crude univariable meta\u2010regression analyses. Six studies (five single\u2010arm open\u2010label studies, one sham\u2010controlled trial) were included. In these, 226 patients underwent IASD implantation using four different devices. From baseline to 12\u2009months, 6MWD increased by 28.1\u00a0m [95% confidence interval (CI) 10.9\u201345.3] with no evidence for a difference between devices (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction\u00a0=\u00a00.66) and patients with left ventricular ejection fraction (LVEF) &gt;40% or \u226440% (\n                      <jats:italic>P<\/jats:italic>\n                      for interaction\u00a0=\u00a00.21). At 12\u2009months, HRQoL improved by 17.7 points (95% CI 10.8\u201324.6) and pulmonary capillary wedge pressure (PCWP) decreased by 2.0\u2009mmHg (95% CI \u22123.6 to \u22120.4). There were no changes in LVEF or N\u2010terminal pro brain natriuretic peptide during follow\u2010up. Shunt patency ranged from 50% for the first\u2010generation v\u2010Wave to 100% for the Corvia IASD II and the second\u2010generation v\u2010Wave system, respectively. The summary risk of serious adverse device\u2010related effects was 8% (95% CI 1\u201320) at 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interatrial shunt device implantation in CHF is feasible and associates with improved submaximal exercise capacity (measured by 6MWD) and HRQoL, and reductions in PCWP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2360","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T13:00:51Z","timestamp":1633870851000},"page":"1960-1970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Feasibility and efficacy of transcatheter interatrial shunt devices for chronic heart failure: a systematic review and meta\u2010analysis"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-9556","authenticated-orcid":false,"given":"Lucas","family":"Lauder","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine Saarland University Medical Center, Saarland University Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago V.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Chevening Scholar, Decision Modelling and Evidence Synthesis University of Leicester Leicester UK"},{"name":"Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus C.","family":"Degenhardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine Saarland University Medical Center, Saarland University Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ewen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine Saarland University Medical Center, Saarland University Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saarraaken","family":"Kulenthiran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine Saarland University Medical Center, Saarland University Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine Saarland University Medical Center, Saarland University Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Berlin\u2010Brandenburg Center for Regenerative Therapies and Department of Cardiology, German Center for Cardiovascular Research Partner Site Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno R.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital University of Toronto Toronto Canada"},{"name":"Institute of Primary Health Care (BIHAM) University of Bern Bern 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