{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:57:40Z","timestamp":1792191460443,"version":"4.4.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Despite aortic stenosis (AS) relief, patients undergoing transcatheter aortic valve implantation (TAVI) are at increased risk of developing heart failure (HF) within first months of intervention. Sodium\u2013glucose co\u2010transporter 2 (SGLT\u20102) inhibitors have been shown to reduce the risk of HF hospitalization in individuals with diabetes mellitus, reduced left ventricular ejection fraction and chronic kidney disease. However, the effect of SGLT\u20102 inhibitors on outcomes after TAVI is unknown. The Dapagliflozin after Transcatheter Aortic Valve Implantation (DapaTAVI) trial is designed to assess the clinical benefit and safety of the SGLT\u20102 inhibitor dapagliflozin in patients undergoing TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      DapaTAVI is an independent pragmatic, controlled, prospective, randomized, open\u2010label blinded endpoint, multicentre trial conducted in Spain, evaluating the effect of dapagliflozin 10\u00a0mg\/day on the risk of death and worsening HF in patients with severe AS undergoing TAVI. Candidate patients should have prior history of HF admission plus \u22651 of the following criteria: (i) diabetes mellitus, (ii) left ventricular ejection fraction \u226440%, or (iii) estimated glomerular filtration rate between 25 and 75\u2009ml\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      . A total of 1020 patients will be randomized (1:1) to dapagliflozin vs. no dapagliflozin. Key secondary outcomes include: (i) incidence rate of individual components of the primary outcome; (ii) cardiovascular mortality; (iii) the composite of HF hospitalization or cardiovascular death; and (iv) total number of HF rehospitalizations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DapaTAVI will determine the efficacy and safety of dapagliflozin in a broad spectrum of frail patients after AS relief by TAVI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2370","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T21:55:52Z","timestamp":1635112552000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Rationale and design of the Dapagliflozin after Transcatheter Aortic Valve Implantation (\n                    <scp>DapaTAVI<\/scp>\n                    ) randomized trial"],"prefix":"10.1093","volume":"24","author":[{"given":"Ignacio J.","family":"Amat\u2010Santos","sequence":"first","affiliation":[{"name":"CIBERCV  Madrid Spain"},{"name":"Cardiology Department Hospital Cl\u00ednico Universitario  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"S\u00e1nchez\u2010Luna","sequence":"additional","affiliation":[{"name":"CIBERCV  Madrid Spain"},{"name":"Cardiology Department Hospital Cl\u00ednico Universitario  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Abu\u2010Assi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital \u00c1lvaro Cunqueiro  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Melendo\u2010Viu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital \u00c1lvaro Cunqueiro  Vigo 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