{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:14:55Z","timestamp":1786378495465,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Community\u2010based data on the association between cardiac autonomic neuropathy (CAN) and incident heart failure (HF) in type 2 diabetes are limited. We evaluated the association of CAN with incident HF in adults with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This analysis included participants from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study without HF at baseline. CAN was assessed by electrocardiogram\u2010based measures of heart rate variability (HRV) and QT interval index (QTI). HRV was measured using standard deviation of all normal\u2010to\u2010normal intervals (SDNN) and root mean square of successive differences between normal\u2010to\u2010normal intervals (rMSSD). CAN was defined using composite measures of the lowest quartile of SDNN and highest quartiles of QTI and heart rate. Multivariable Cox regression models were used to generate adjusted hazard ratios (aHR) for HF in relation to various CAN measures. A total of 7160 participants (mean age 62.3 [standard deviation 6.4] years, 40.8% women, 61.9% white) were included. Over a median follow\u2010up of 4.9\u2009years (interquartile range 4.0\u20135.7), 222 participants developed incident HF. After multivariable adjustment for relevant confounders, lower HRV as assessed by SDNN was associated with a higher risk of HF (aHR for the lowest vs highest quartile of SDNN: 1.70, 95% confidence interval [CI] 1.14\u20132.54). Participants with CAN (defined as lowest quartile of SDNN and highest quartiles of QTI and heart rate) had a 2.7\u2010fold greater risk of HF (aHR 2.65, 95% CI 1.57\u20134.48).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a large cohort of adults with type 2 diabetes, CAN was independently associated with higher risk of incident HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2432","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T06:33:09Z","timestamp":1642833189000},"page":"634-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cardiac autonomic neuropathy and risk of incident heart failure among adults with type 2 diabetes"],"prefix":"10.1093","volume":"24","author":[{"given":"Arnaud D.","family":"Kaze","sequence":"first","affiliation":[{"name":"Department of Medicine SOVAH Health  Danville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Yuyun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Harvard Medical School &amp; Veteran Affairs Boston Healthcare System  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebhat","family":"Erqou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Providence VA Medical Center and Alpert Medical School of Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Ahmanson\u2010UCLA Cardiomyopathy Center Ronald Reagan UCLA Medical Center  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin 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