{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:31:05Z","timestamp":1787711465149,"version":"build-2784847793"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Intravenous ferric carboxymaltose (FCM) has been shown to improve overall quality of life in iron\u2010deficient heart failure with reduced ejection fraction (HFrEF) patients at a trial population level. This FAIR\u2010HF and CONFIRM\u2010HF pooled analysis explored the likelihood of individual improvement or deterioration in Kansas City Cardiomyopathy Questionnaire (KCCQ) domains with FCM versus placebo and evaluated the stability of this response over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Changes versus baseline in KCCQ overall summary score (OSS), clinical summary score (CSS) and total symptom score (TSS) were assessed at weeks 12 and 24 in FCM and placebo groups. Mean between\u2010group differences were estimated and individual responder analyses and analyses of response stability were performed. Overall, 760 (FCM,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0454) patients were studied. At week 12, the mean improvement in KCCQ OSS was 10.6 points with FCM versus 4.8 points with placebo (least\u2010square mean difference [95% confidence interval, CI] 4.36 [2.14;\u20096.59] points). A higher proportion of patients on FCM versus placebo experienced a KCCQ OSS improvement of \u22655 (58.3% vs. 43.5%; odds ratio [95% CI] 1.81 [1.30;\u20092.51]), \u226510 (42.4% vs. 29.3%; 1.73 [1.23;\u20092.43]) or \u226515 (32.1% vs. 22.6%; 1.46 [1.02;\u20092.11]) points. Differences were similar at week 24 and for CSS and TSS domains. Of FCM patients with a \u22655\u2010, \u226510\u2010 or \u226515\u2010point improvement in KCCQ OSS at week 12, &gt;75% sustained this improvement at week 24.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment of iron\u2010deficient HFrEF patients with intravenous FCM conveyed clinically relevant improvements in health status at an individual\u2010patient level; benefits were sustained over time in most patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2478","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T08:39:20Z","timestamp":1647160760000},"page":"821-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Health status improvement with ferric carboxymaltose in heart failure with reduced ejection fraction and iron deficiency"],"prefix":"10.1093","volume":"24","author":[{"given":"Javed","family":"Butler","sequence":"first","affiliation":[{"name":"Department of Medicine University of Mississippi  Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke University Medical Center  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Friede","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa A.","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Fabien","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd.  Glattbrugg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo\u2010Michael","family":"Goehring","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd.  Glattbrugg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Dorigotti","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd.  Glattbrugg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[{"name":"Department of Cardiology University and Civil Hospital  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana L.","family":"Pi\u00f1a","sequence":"additional","affiliation":[{"name":"Central Michigan University  Mount Pleasant MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rosano","sequence":"additional","affiliation":[{"name":"Centre for Clinical and Basic Research, Department of Medical Sciences IRCCS San Raffaele Pisana  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Comin\u2010Colet","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bellvitge University Hospital  Barcelona Spain"},{"name":"IDIBELL (Institute of Biomedical Investigation of Bellvitge) University of Barcelona, Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"Van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos S.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens Athens University Hospital Attikon  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK) Berlin Institute of Health Center for Regenerative Therapies (BCRT)  Berlin Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Berlin partner site Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.027"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.03.169"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2011.08.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02434-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2017.1351239"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11030082"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12400"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.823"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32339-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027497"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182949a2e"},{"key":"e_1_2_6_15_1","unstructured":"Center for Drug Evaluation and Research (CDER). 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