{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:04:08Z","timestamp":1788350648106,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Ferric carboxymaltose (FCM) improves left ventricular function in heart failure with reduced ejection fraction (HFrEF). Yet, the effect of FCM on right ventricular (RV) function remains insufficiently elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      This is a pre\u2010defined analysis of the IRON\u2010CRT trial in which symptomatic HFrEF patients with iron deficiency and reduced left ventricular ejection fraction (LVEF) despite optimal medical therapy and cardiac resynchronization therapy (CRT) underwent 1:1 randomization to FCM or placebo in a double\u2010blind fashion. RV function was measured as the change from baseline to 3\u2010month follow\u2010up in RV fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE) and pulsed Doppler peak velocity at the RV lateral annulus (RV S\u2032), systolic pulmonary artery pressure (SPAP) and its coupling to the right ventricle (TAPSE\/SPAP ratio). The RV contractile reserve was measured as the change in TAPSE during incremental pacing at 70, 90 and 110 bpm. A total of 75 patients underwent randomization and received FCM (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a038). At baseline 72.5% had RV dysfunction and 70% had RV dilatation. At 3\u2010month follow\u2010up, patients receiving FCM had a significant improvement in RV FAC (+4.1% [+1.4%\u2009\u2212\u2009+6.9%] vs. \u22122.2% [\u22124.9%\u2009\u2212\u2009+0.6%] in the placebo group,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) and TAPSE (+0.98\u2009mm [+0.28\u2009mm\u2009\u2212\u2009+1.62\u2009mm] vs. \u22120.19\u2009mm [\u22120.85\u2009mm\u2009\u2212\u2009+0.48\u2009mm] in the placebo group,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.020), but not RV S\u2032. Patients receiving FCM had a numerically lower SPAP (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.073) and significant improvement in TAPSE\/SPAP ratio (+0.097 [+0.048\u2009\u2212\u2009+0.146] vs. +0.002 [\u22120.046\u2009\u2212\u2009+0.051] in the placebo group,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008). At baseline both groups had diminished RV contractile reserve during incremental pacing, which was attenuated at 3\u2010month follow\u2010up in the FCM group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004). Patients manifesting more RV function improvement were more likely to exhibit higher degrees of LVEF improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with FCM in HFrEF patients results in an improvement in RV function and structure and improves the RV contractile reserve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2489","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T13:38:09Z","timestamp":1647610689000},"page":"1106-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The effect of intravenous ferric carboxymaltose on right ventricular function \u2013 insights from the\n                    <scp>IRON\u2010CRT<\/scp>\n                    trial"],"prefix":"10.1093","volume":"24","author":[{"given":"Pieter","family":"Martens","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic  Cleveland OH USA"},{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Dauw","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Nijst","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe B","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.H. Wilson","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Mullens","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg  Genk Belgium"},{"name":"Data Science Institute, Centrum for Statistics (CenStat) University Hasselt  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq158"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.01.017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2017.1351239"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1154"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1174"},{"key":"e_1_2_6_7_1","first-page":"362","article-title":"Iron\u2010regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure","volume":"38","author":"Haddad S","year":"2017","journal-title":"Eur Heart 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