{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:18:42Z","timestamp":1774477122693,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Improving functional capacity is a key goal in heart failure (HF). This pooled analysis of FAIR\u2010HF and CONFIRM\u2010HF assessed the likelihood of improvement or deterioration in 6\u2010min walk test (6MWT) among iron\u2010deficient patients with chronic HF with reduced ejection fraction (HFrEF) receiving ferric carboxymaltose (FCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Data for 760 patients (FCM:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0454; placebo:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0306) were analysed. The proportions of patients receiving FCM or placebo who had \u226520, \u226530, and\u2009\u226540\u2009m improvements or \u226510\u2009m deterioration in 6MWT at 12 and 24\u2009weeks were assessed. Patients receiving FCM experienced a mean (standard deviation) 31.1 (62.3)\u00a0m improvement in 6MWT versus 0.1 (77.1)\u00a0m improvement for placebo at week 12 (difference in mean changes 26.8 [16.6\u201337.0]). At week 12, the odds [95% confidence interval] of 6MWT improvements of \u226520\u2009m (odds ratio 2.16 [1.57\u20132.96];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), \u226530\u2009m (2.00 [1.44\u20132.78];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and \u226540\u2009m (2.29 [1.60\u20133.27];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) were greater with FCM versus placebo, while the odds of a deterioration \u226510\u00a0m were reduced with FCM versus placebo (0.55 [0.38\u20130.80];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0019). Among patients who experienced 6MWT improvements of \u226520, \u226530, or \u226540\u2009m with FCM at week 12, more than 80% sustained this improvement at week 24.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ferric carboxymaltose resulted in a significantly higher likelihood of improvement and a reduced likelihood of deterioration in 6MWT versus placebo among iron\u2010deficient patients with HF. Of the patients experiencing clinically significant improvements at week 12, the majority sustained this improvement at week 24. These results are supportive of FCM to improve exercise capacity in HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2491","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T12:56:30Z","timestamp":1648212990000},"page":"833-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Responder analysis for improvement in 6\u2010min walk test with ferric carboxymaltose in patients with heart failure with reduced ejection fraction and iron deficiency"],"prefix":"10.1093","volume":"24","author":[{"given":"Stefan D.","family":"Anker","sequence":"first","affiliation":[{"name":"Department of Cardiology (CVK); and Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Center for Cardiovascular Research (DZHK) partner site Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Institute of Heart Diseases Wroclaw Medical University  Wroclaw Poland"},{"name":"Institute of Heart Diseases University Hospital in Wroclaw  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Friede","sequence":"additional","affiliation":[{"name":"G\u00f6ttingen, Germany; DZHK (German Center for Cardiovascular Research), G\u00f6ttingen partner site University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa A.","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Fabien","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd.  Glattbrugg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo\u2010Michael","family":"Goehring","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd.  Glattbrugg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[{"name":"Cardiology University and Civil Hospital  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ileana L.","family":"Pi\u00f1a","sequence":"additional","affiliation":[{"name":"Central Michigan University  Mount Pleasant MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.S.","family":"Coats","sequence":"additional","affiliation":[{"name":"University of Warwick  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rosano","sequence":"additional","affiliation":[{"name":"Centre for Clinical and Basic Research, Department of Medical Sciences IRCCS San Raffaele Pisana  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Dorigotti","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd.  Glattbrugg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Comin\u2010Colet","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bellvitge University Hospital; IDIBELL, University of Barcelona, Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J.","family":"Van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos S.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus  Nicosia Cyprus"},{"name":"School of Medicine of National and Kapodistrian University of Athens Athens University Hospital Attikon  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Mississippi  Jackson MS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.1161"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305669"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2333"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027497"},{"key":"e_1_2_6_6_1","unstructured":"US Food and Drug Administration.Treatment for Heart Failure: Endpoints for Drug Development Guidance for Industry June2019.https:\/\/www.fda.gov\/media\/128372\/download. 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