{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:47:03Z","timestamp":1793785623465,"version":"4.6.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transcatheter mitral valve implantation (TMVI) represents a novel treatment option for patients with mitral regurgitation (MR) unsuitable for established therapies. The CHOICE\u2010MI registry aimed to investigate outcomes of patients undergoing screening for TMVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      From May 2014 to March 2021, patients with MR considered suboptimal candidates for transcatheter edge\u2010to\u2010edge repair (TEER) and at high risk for mitral valve surgery underwent TMVI screening at 26 centres. Characteristics and outcomes were investigated for patients undergoing TMVI and for TMVI\u2010ineligible patients referred to bailout\u2010TEER, high\u2010risk surgery or medical therapy (MT). The primary composite endpoint was all\u2010cause mortality or heart failure hospitalization after 1\u00a0year. Among 746 patients included (78.5\u2009years, interquartile range [IQR] 72.0\u201383.0, EuroSCORE II 4.7% [IQR 2.7\u20139.7]), 229 patients (30.7%) underwent TMVI with 10 different dedicated devices. At 1\u00a0year, residual MR \u22641+ was present in 95.2% and the primary endpoint occurred in 39.2% of patients treated with TMVI. In TMVI\u2010ineligible patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0517, 69.3%), rates of residual MR \u22641+ were 37.2%, 100.0% and 2.4% after bailout\u2010TEER, high\u2010risk surgery and MT, respectively. The primary endpoint at 1\u00a0year occurred in 28.8% of patients referred to bailout\u2010TEER, in 42.9% of patients undergoing high\u2010risk surgery and in 47.9% of patients remaining on MT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This registry included the largest number of patients treated with TMVI to date. TMVI with 10 dedicated devices resulted in predictable MR elimination and sustained functional improvement at 1\u00a0year. In TMVI\u2010ineligible patients, bailout\u2010TEER and high\u2010risk surgery represented reasonable alternatives, while MT was associated with poor clinical and functional outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2492","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T01:03:49Z","timestamp":1648256629000},"page":"887-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Characteristics and outcomes of patients screened for transcatheter mitral valve implantation:\n                    <scp>1\u2010year<\/scp>\n                    results from the\n                    <scp>CHOICE\u2010MI<\/scp>\n                    registry"],"prefix":"10.1093","volume":"24","author":[{"given":"Walid","family":"Ben Ali","sequence":"first","affiliation":[{"name":"Montreal Heart Institute Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ludwig","sequence":"additional","affiliation":[{"name":"University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK): Partner site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"},{"name":"Cardiovascular Research Foundation New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Duncan","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Weimann","sequence":"additional","affiliation":[{"name":"University Heart and Vascular Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Heart Center Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Heart Center Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Coisne","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Vincentelli","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Webb","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariama","family":"Akodad","sequence":"additional","affiliation":[{"name":"St. Paul's Hospital Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.M.","family":"Muller","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Praz","sequence":"additional","affiliation":[{"name":"Bern University Hospital Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam G.","family":"Wild","sequence":"additional","affiliation":[{"name":"Bern University Hospital Bern Switzerland"},{"name":"Ludwig Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[{"name":"Ludwig Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin S.","family":"Goel","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz Wyler","family":"von Ballmoos","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Ospedale San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Chehab","sequence":"additional","affiliation":[{"name":"St. Thomas' Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Redwood","sequence":"additional","affiliation":[{"name":"St. Thomas' Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry","family":"Dahle","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Adam","sequence":"additional","affiliation":[{"name":"University Hospital of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Ruge","sequence":"additional","affiliation":[{"name":"German Heart Center Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Lange","sequence":"additional","affiliation":[{"name":"German Heart Center Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Leroux","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dumonteil","sequence":"additional","affiliation":[{"name":"Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Tchetche","sequence":"additional","affiliation":[{"name":"Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Treede","sequence":"additional","affiliation":[{"name":"Heart Valve Center, Heart and Vascular Center Universit\u00e4tsmedizin Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Flagiello","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Louis Pradel Cardiologic Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Francois","family":"Obadia","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Louis Pradel Cardiologic Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walther","sequence":"additional","affiliation":[{"name":"Frankfurt University Hospital Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"HerzZentrum Hirslanden Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Bleiziffer","sequence":"additional","affiliation":[{"name":"Heart and Diabetes Center NRW Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja K.","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Heart and Diabetes Center NRW Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Fam","sequence":"additional","affiliation":[{"name":"St. Michael's Hospital, University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"German Heart Center Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Granada","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert H.L.","family":"Tang","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Heart Valve Center, Heart and Vascular Center Universit\u00e4tsmedizin Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenard","family":"Conradi","sequence":"additional","affiliation":[{"name":"University Heart and Vascular Center Hamburg Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK): Partner site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Modine","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CHOICE\u2010MI Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.723"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311412"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1774"},{"key":"e_1_2_7_9_1","article-title":"Management of patients with mitral regurgitation ineligible for standard therapy undergoing TMVI screening","author":"Ludwig S","year":"2022","journal-title":"EuroIntervention"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-021-01466-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.08.060"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.10.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.061"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-01051"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00444"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.049"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.066"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.12.038"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012525"},{"key":"e_1_2_7_20_1","article-title":"Early outcomes of transcatheter mitral valve replacement with the Tendyne system in severe mitral annular calcification","author":"G\u00f6ssl M","year":"2021","journal-title":"EuroIntervention"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.069"},{"key":"e_1_2_7_22_1","unstructured":"Global EXPAND: Next\u2010Gen MitraClipCutsMR Boosts QoL at 1 Year. October 16 2020.https:\/\/www.tctmd.com\/news\/global\u2010expand\u2010next\u2010gen\u2010mitraclip\u2010cuts\u2010mr\u2010boosts\u2010qol\u20101\u2010year. Accessed 30 March 2022."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.10.042"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"E294","DOI":"10.25270\/jic\/20.00407","article-title":"Characteristics and outcomes of patients ineligible for transcatheter mitral valve replacement (TMVR): implications for future device innovation","volume":"33","author":"Ludwig S","year":"2021","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab086"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:16:25Z","timestamp":1767701785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,17]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/ejhf.2492"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2492","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,17]]},"assertion":[{"value":"2022-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}