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A strategy for outpatient intravenous (IV) diuretic treatment of WHF has been developed in certain American centres in the past 10\u2009years, whereas European centres have been mostly favouring \u2018classic\u2019 in\u2010hospital management of WHF. Embracing novel, outpatient approaches for treating WHF could substantially reduce the burden on healthcare systems while improving patient's satisfaction and quality of life. The present article is intended to provide essential knowledge and practical guidelines aimed at helping clinicians implement these new ambulatory approaches using day hospital and\/or at\u2010home hospitalization. The topics addressed by our group of HF experts include the pathophysiological background of diuretic therapy, the most suitable profile of WHF that may be managed in an ambulatory setting, the pharmacological protocols that can be used, as well as a detailed description of healthcare structures that can be proposed to deliver these ambulatory care interventions. The practical aspects of day hospital and hospital\u2010at\u2010home IV diuretic administration are specifically emphasized. The algorithm provided along with the practical IV diuretic protocols should assist HF clinicians in implementing this new approach in their local clinical setting.<\/jats:p>","DOI":"10.1002\/ejhf.2503","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:01:05Z","timestamp":1649847665000},"page":"750-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Practical outpatient management of worsening chronic heart failure"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-2057","authenticated-orcid":false,"given":"Nicolas","family":"Girerd","sequence":"first","affiliation":[{"name":"Centre d'Investigation Clinique\u2010 Plurith\u00e9matique Inserm CIC\u2010P 1433, Inserm U1116, CHRU Nancy Brabois, F\u2010CRIN INI\u2010CRCT (Cardiovascular and Renal Clinical Trialists) Universit\u00e9 de Lorraine  Nancy 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