{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:07:12Z","timestamp":1791446832656,"version":"4.3.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The recent definition of heart failure with improved ejection fraction outlined the importance of the longitudinal assessment of left ventricular ejection fraction (LVEF). However, long\u2010term progression and outcomes of this subgroup are poorly explored. We sought to assess the LVEF trajectories and their correlations with outcome in non\u2010ischaemic dilated cardiomyopathy (NICM) with improved ejection fraction (impEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Consecutive NICM patients with baseline LVEF \u226440% enrolled in the Trieste Heart Muscle Disease Registry with \u22651 LVEF assessment after baseline were included. ImpEF was defined as a baseline LVEF \u226440%, and second evaluation showing both a \u226510% point increase from baseline LVEF and LVEF &gt;40%. Transient impEF was defined by the documentation of recurrent LVEF \u226440% during follow\u2010up. The primary endpoint was a composite of all\u2010cause death, heart transplantation and left ventricular assist device (D\/HT\/LVAD). Among 800 patients, 460 (57%) had impEF (median time to improvement 13\u2009months). Transient impEF was observed in 189 patients (41% of the overall impEF group) and was associated with higher risk of D\/HT\/LVAD compared with persistent impEF at multivariable analysis (hazard ratio 2.54; 95% confidence interval 1.60\u20134.04). The association of declining LVEF with the risk of D\/HT\/LVAD was non\u2010linear, with a steep increase up to 8% points reduction, then remaining stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In NICM, a 57% rate of impEF was observed. However, recurrent decline in LVEF was observed in \u224840% of impEF patients and it was associated with an increased risk of D\/HT\/LVAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2512","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T23:23:30Z","timestamp":1650669810000},"page":"1171-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Transient versus persistent improved ejection fraction in non\u2010ischaemic dilated cardiomyopathy"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-9657","authenticated-orcid":false,"given":"Paolo","family":"Manca","sequence":"first","affiliation":[{"name":"Cardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Stolfo","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste  Trieste Italy"},{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Gregorio","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Department of Medical Sciences University of Trieste  Trieste Italy"},{"name":"MOX\u00a0\u2013\u00a0Department of Mathematics Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cannat\u00e0","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste  Trieste Italy"},{"name":"Department of Cardiovascular Science, Faculty of Life Science and Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ramani","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Nuzzi","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Savarese","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardiothoracovascular Department Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2003.10.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.824"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.030"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006855"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.11.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001504"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2115"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.042"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32484-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1103"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.08.062"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy076"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2380"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_7_17_1","unstructured":"European Society of Cardiology (ESC); 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