{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:50:13Z","timestamp":1792615813793,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiac resynchronization therapy (CRT) reduces morbidity and mortality for patients with heart failure, reduced left ventricular ejection fraction, QRS duration &gt;130\u2009ms and in sinus rhythm. The aim of this study was to identify patient characteristics that predict the effect, specifically, of CRT pacemakers (CRT\u2010P) on all\u2010cause mortality or the composite of hospitalization for heart failure or all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We conducted an individual patient data meta\u2010analysis of the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) and Cardiac Resynchronization\u2010Heart Failure (CARE\u2010HF) trials. Only patients assigned to CRT\u2010P or control (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01738) were included in order to avoid confounding from concomitant defibrillator therapy. The influence of baseline characteristics on treatment effects was investigated. Median age was 67 (59\u201373) years, most patients were men (70%), 68% had a QRS duration of 150\u2013199\u2009ms and 80% had left bundle branch block. Patients assigned to CRT\u2010P had lower rates for all\u2010cause mortality (hazard ratio [HR] 0.68, 95% confidence interval [CI] 0.56\u20130.81;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and the composite outcome (HR 0.67, 95% CI 0.58\u20130.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No pre\u2010specified characteristic, including sex, aetiology of ventricular dysfunction, QRS duration (within the studied range) or morphology or PR interval significantly influenced the effect of CRT\u2010P on all\u2010cause mortality or the composite outcome. However, CRT\u2010P had a greater effect on the composite outcome for patients with lower body surface area and those prescribed beta\u2010blockers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiac resynchronization therapy\u2010pacemaker reduces morbidity and mortality in appropriately selected patients with heart failure. Benefits may be greater in smaller patients and in those receiving beta\u2010blockers. Neither QRS duration nor morphology independently predicted the benefit of CRT\u2010P.<\/jats:p>\n                    <jats:p>Clinical Trial Registration: COMPANION, NCT00180258; CARE\u2010HF, NCT00170300.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2524","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T04:44:56Z","timestamp":1651380296000},"page":"1080-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an\n                    <scp>individual patient data meta\u2010analysis<\/scp>\n                    of\n                    <scp>COMPANION<\/scp>\n                    and\n                    <scp>CARE\u2010HF<\/scp>"],"prefix":"10.1093","volume":"24","author":[{"given":"John G.F.","family":"Cleland","sequence":"first","affiliation":[{"name":"Robertson Centre for Biostatistics &amp; Clinical Trials University of Glasgow &amp; National Heart &amp; Lung Institute, Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Bristow","sequence":"additional","affiliation":[{"name":"University of Colorado Cardiovascular Institute, Aurora and Boulder  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Freemantle","sequence":"additional","affiliation":[{"name":"Institute of Clinical Trials and Methodology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Olshansky","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City &amp; Mercy Hospital \u2010 North Iowa  Mason City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gras","sequence":"additional","affiliation":[{"name":"Hopital Prive du Confluent  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Saxon","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital\u00a0\u2013\u00a0GVM Care &amp;Research  Cotignola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Boehmer","sequence":"additional","affiliation":[{"name":"Penn State Hershey Medical Center  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ghio","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur M.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Lewis Katz School of Medicine at Temple University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Daubert","sequence":"additional","affiliation":[{"name":"University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"de Mets","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health  Madison WI 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