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We examined the prevalence of CA in different settings based on literature data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We performed a systematic search for screening studies on CA, focusing on the prevalence, sex and age distribution in different clinical settings. The prevalence of CA in different settings was as follows: bone scintigraphy for non\u2010cardiac reasons (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05 studies), 1% (95% confidence interval [CI] 0%\u20131%); heart failure with preserved ejection fraction (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06), 12% (95% CI 6%\u201320%); heart failure with reduced or mildly reduced ejection fraction (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02), 10% (95% CI 6%\u201315%); conduction disorders warranting pacemaker implantation (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01), 2% (95% CI 0%\u20134%); surgery for carpal tunnel syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03), 7% (95% CI 5%\u201310%); hypertrophic cardiomyopathy phenotype (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02), 7% (95% CI 5%\u20139%); severe aortic stenosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07), 8% (95% CI 5%\u201313%); autopsy series of \u2018unselected\u2019 elderly individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04), 21% (95% CI 7%\u201339%). The average age of CA patients in the different settings ranged from 74 to 90\u2009years, and the percentage of men from 50% to 100%. Many patients had ATTR\u2010CA, but the average percentage of patients with amyloid light\u2010chain (AL) CA was up to 18%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Searching for CA in specific settings allows to identify a relatively high number of cases who may be eligible for treatment if the diagnosis is unequivocal. ATTR\u2010CA accounts for many cases of CA across the different settings, but AL\u2010CA is not infrequent. Median age at diagnosis falls in the eighth or ninth decades, and many patients diagnosed with CA are women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2532","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T01:11:31Z","timestamp":1651713091000},"page":"2342-2351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":212,"title":["Redefining the epidemiology of cardiac amyloidosis. A systematic review and meta\u2010analysis of screening studies"],"prefix":"10.1093","volume":"24","author":[{"given":"Alberto","family":"Aimo","sequence":"first","affiliation":[{"name":"Scuola Superiore Sant'Anna  Pisa Italy"},{"name":"Cardiology Division Fondazione Toscana Gabriele Monasterio  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Centre for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano\u2010Isontina (ASUGI), University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldostefano","family":"Porcari","sequence":"additional","affiliation":[{"name":"Centre for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano\u2010Isontina (ASUGI), University of Trieste  Trieste 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