{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:36:02Z","timestamp":1790188562181,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The incidence and risk factors of pacemaker (PM) implantation in patients with cardiac amyloidosis (CA) are largely unexplored. We sought to characterize the trends in the incidence of permanent PM and to identify baseline predictors of future PM implantation in light\u2010chain (AL) and transthyretin (ATTR) CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Consecutive patients with AL and ATTR\u2010CA diagnosed at participating centres (2017\u20132020) were included. Clinical data recorded within \u00b11\u00a0month from diagnosis were collected from electronic medical records. The primary study outcome was the need for clinically\u2010indicated PM implantation. Patients with PM (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a041) and\/or permanent defibrillator in situ (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013) at CA diagnosis were excluded. The study population consisted of 405 patients: 29.4% AL, 14.6% variant ATTR and 56% wild\u2010type ATTR; 82.5% were male, median age 76\u2009years. During a median follow\u2010up of 33\u2009months (interquartile range 21\u201346), 36 (8.9%) patients experienced the primary outcome: 10 AL\u2010CA, 2 variant ATTR\u2010CA and 24 wild\u2010type ATTR\u2010CA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.08 at time\u2010to\u2010event analysis). At multivariable analysis, history of atrial fibrillation (hazard ratio [HR] 3.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), PR interval (HR 1.013,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) and QRS &gt;120\u2009ms (HR 4.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) on baseline electrocardiogram were independently associated with PM implantation. The absence of these three factors had a negative predictive value of 92% with an area under the curve of 91.8% at 6\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a large cohort of AL and ATTR\u2010CA patients, 8.9% received a PM within 3\u2009years after diagnosis. History of atrial fibrillation, PR &gt;200\u2009ms and QRS &gt;120\u2009ms predicted future PM implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2533","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T01:11:39Z","timestamp":1651713099000},"page":"1227-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Incidence and risk factors for pacemaker implantation in light\u2010chain and transthyretin cardiac amyloidosis"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3307-0825","authenticated-orcid":false,"given":"Aldostefano","family":"Porcari","sequence":"first","affiliation":[{"name":"Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department Azienda Sanitaria Universitaria Giuliano\u2010Isontina (ASUGI), University of Trieste  Trieste 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