{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:44:21Z","timestamp":1792899861656,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In heart failure (HF) with preserved ejection fraction (HFpEF), excessive redistribution of blood volume into the central circulation leads to elevations of intracardiac pressures with exercise limitations. Splanchnic ablation for volume management (SAVM) has been proposed as a therapeutic intervention. Here we present preliminary safety and efficacy data from the initial roll\u2010in cohort of the REBALANCE\u2010HF trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      The open\u2010label (roll\u2010in) arm of REBALANCE\u2010HF will enrol up to 30 patients, followed by the randomized, sham\u2010controlled portion of the trial (up to 80 additional patients). Patients with HF, left ventricular ejection fraction (LVEF) \u226550%, and invasive peak exercise pulmonary capillary wedge pressure (PCWP) \u226525\u2009mmHg underwent SAVM. Baseline and follow\u2010up assessments included resting and exercise PCWP, New York Heart Association (NYHA) class, Kansas City Cardiomyopathy Questionnaire (KCCQ), 6\u2010min walk test, and N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP). Efficacy and safety were assessed at 1 and 3\u2009months. Here we report on the first 18 patients with HFpEF that have been enrolled into the roll\u2010in, open\u2010label arm of the study across nine centres; 14 (78%) female; 16 (89%) in NYHA class III; and median (interquartile range) age 75.2 (68.4\u201381) years, LVEF 61.0 (56.0\u201363.2)%, and average (standard deviation) 20\u2009W exercise PCWP 36.4 (\u00b18.6) mmHg. All 18 patients were successfully treated. Three non\u2010serious moderate device\/procedure\u2010related adverse events were reported. At 1\u2010month, the mean PCWP at 20\u2009W exercise decreased from 36.4 (\u00b18.6) to 28.9 (\u00b17.8) mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.01), NYHA class improved by at least one class in 33% of patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.02) and KCCQ score improved by 22.1 points (95% confidence interval 9.4\u201334.2) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The preliminary open\u2010label results from the multicentre REBALANCE\u2010HF roll\u2010in cohort support the safety and efficacy of SAVM in HFpEF. The findings require confirmation in the ongoing randomized, sham\u2010controlled portion of the trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2559","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T07:34:29Z","timestamp":1653204869000},"page":"1410-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction: early results of the\n                    <scp>REBALANCE\u2010HF<\/scp>\n                    trial roll\u2010in cohort"],"prefix":"10.1093","volume":"24","author":[{"given":"Marat","family":"Fudim","sequence":"first","affiliation":[{"name":"Duke University Medical Center  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Fail","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute of the South  Houma LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon E.","family":"Litwin","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina and Ralph H. Johnson, Veterans Affairs Medical Center  Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaz","family":"Shaburishvili","sequence":"additional","affiliation":[{"name":"Tbilisi Heart and Vascular Clinic  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Goyal","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine  New Yok NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Hummel","sequence":"additional","affiliation":[{"name":"Michigan School of Medicine University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Mayo Clinic, College of Medicine  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev C.","family":"Mohan","sequence":"additional","affiliation":[{"name":"Scripps Clinic  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet S.","family":"Mitter","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital \u2010 Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Klein","sequence":"additional","affiliation":[{"name":"University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Rocha\u2010Singh","sequence":"additional","affiliation":[{"name":"Prairie Heart Institute at St. John's Hospital  Springfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manesh R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Duke University Medical Center  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Y.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital \u2010 Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy268"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.03.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu315"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.009340"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2196"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-019-09929-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00069.2017"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.048"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy682"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.04.010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2209"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.02.005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2254"}],"container-title":["European Journal of Heart 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