{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:47Z","timestamp":1785150527870,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the role of left atrial volume index (LAVi) in patients with secondary mitral regurgitation (SMR) undergoing transcatheter edge\u2010to\u2010edge mitral valve repair (TEER).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Outcomes were evaluated in SMR patients of a European multicentre registry according to baseline LAVi. Main analysis was performed for all\u2010cause mortality; residual mitral regurgitation (MR) and New York Heart Association (NYHA) class improvement were analysed for patients available. A total of 1074 patients were included with a median LAVi (interquartile range) of 58\u2009ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      (46\u201373). Postprocedural reduction of MR grade to \u22642+ was similar across LAVi quintiles, ranging 91%\u201396% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.26). Symptomatic benefit (\n                      <jats:styled-content>\u2265<\/jats:styled-content>\n                      1 NYHA class improvement) also did not differ by LAVi quintiles (61%\u201368% of patients) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.66). The risk of mortality increased by 23%\u201342% in the four upper quintiles compared to the bottom quintile (LAVi &lt;42\u2009ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). The hazard ratio (HR) of mortality was 1.35 (95% confidence interval [CI] 1.02\u20131.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.035) associated with a LAVi &gt;42\u2009ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      , which was attenuated after multivariable adjustment (HR 1.18, 95% CI 0.83\u20131.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.36). A significant interaction was found for MR severity and pulmonary hypertension, with an increased risk of death associated with enlarged LAVi in patients with inframedian effective regurgitant orifice area (HR 1.99, 95% CI 1.06\u20133.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.032) and in patients with systolic pulmonary pressure \u226450\u2009mmHg (HR 1.67, 95% CI 1.02\u20132.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.042) in multivariable analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Procedural success and symptomatic benefit were high throughout the whole range of LAVi. The prognostic impact of left atrial enlargement was relevant in patients with less severe SMR and without pulmonary hypertension, reinforcing the need to identify patients in the early course of backward congestion to achieve good long\u2010term outcome after TEER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2565","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T08:37:16Z","timestamp":1654072636000},"page":"1282-1292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Left atrial volume index and outcome after transcatheter edge\u2010to\u2010edge valve repair for secondary mitral regurgitation"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-8500","authenticated-orcid":false,"given":"Christos","family":"Iliadis","sequence":"first","affiliation":[{"name":"Department III of Internal Medicine, Heart Center University of Cologne, Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kalbacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg  Hamburg Germany"},{"name":"German Center for Cardiovascular Research, Partner Site Hamburg\/Kiel\/L\u00fcbeck, DZHK  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniela Monica","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Heart Valve Center Mainz, Center for Cardiology, Cardiology I, University Medical Center Mainz Johannes Gutenberg\u2010Universit\u00e4t  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Orban","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Klinikum der Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Puscas","sequence":"additional","affiliation":[{"name":"European Hospital Georges Pompidou (Department of Cardiology) and Paris Cardiovascular Research Center (INSERM U970)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lupi","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory and Cardiology ASST Spedali Civili and University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Stazzoni","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Pires\u2010Morais","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Vila Nova de Gaia  Espinho Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Koell","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg  Hamburg Germany"},{"name":"German Center for Cardiovascular Research, Partner Site Hamburg\/Kiel\/L\u00fcbeck, DZHK  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Besler","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Friedrich","family":"Ruf","sequence":"additional","affiliation":[{"name":"Heart Valve Center Mainz, Center for Cardiology, Cardiology I, University Medical Center Mainz Johannes Gutenberg\u2010Universit\u00e4t  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Stolz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Klinikum der Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemie","family":"Tence","sequence":"additional","affiliation":[{"name":"European Hospital Georges Pompidou (Department of Cardiology) and Paris Cardiovascular Research Center (INSERM U970)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory and Cardiology ASST Spedali Civili and University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Giannini","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory, Cardiothoracic and Vascular Department University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Vila Nova de Gaia  Espinho Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hellmich","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine, Heart Center University of Cologne, Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Schofer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Heart Valve Center Mainz, Center for Cardiology, Cardiology I, University Medical Center Mainz Johannes Gutenberg\u2010Universit\u00e4t  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Klinikum der Universit\u00e4t M\u00fcnchen  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Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine, Heart Center University of Cologne, Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-017-1150-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805374"},{"key":"e_1_2_7_5_1","first-page":"e72","article-title":"2020 ACC\/AHA Guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto 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Journal of Heart 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