{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:19:27Z","timestamp":1793420367473,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/0765 & PI20\/01379"],"award-info":[{"award-number":["PI18\/0765 & PI20\/01379"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013125","name":"Blond McIndoe Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Although systemic embolism is a potential complication in transthyretin amyloid cardiomyopathy (ATTR\u2010CM), data about its incidence and prevalence are scarce. We studied the incidence, prevalence and factors associated with embolic events in ATTR\u2010CM. Additionally, we evaluated embolic events according to the type of oral anticoagulation (OAC) and the performance of the CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc score in this setting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Clinical characteristics, history of atrial fibrillation (AF) and embolic events were retrospectively collected from ATTR\u2010CM patients evaluated at four international amyloid centres. Overall, 1191 ATTR\u2010CM patients (87% men, median age 77.1\u2009years [interquartile range\u2010IQR 71.4\u201382], 83% ATTRwt) were studied. A total of 162 (13.6%) have had an embolic event before initial evaluation. Over a median follow\u2010up of 19.9 months (IQR 9.9\u201335.5), 41 additional patients (3.44%) had an embolic event. Incidence rate (per 100 patient\u2010years) was 0 among patients in sinus rhythm with OAC, 1.3 in sinus rhythm without OAC, 1.7 in AF with OAC, and 4.8 in AF without OAC. CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc did not predict embolic events in patients in sinus rhythm whereas in patients with AF without OAC, only those with a score \u22654 had embolic events. There was no difference in the incidence rate of embolism between patients with AF treated with vitamin K antagonists (VKAs) (\n                      <jats:italic>n<\/jats:italic>\n                      = 322) and those treated with direct oral anticoagulants (DOACs) (\n                      <jats:italic>n<\/jats:italic>\n                      = 239) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.66).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Embolic events were a frequent complication in ATTR\u2010CM. OAC reduced the risk of systemic embolism. Embolic rates did not differ with VKAs and DOACs. The CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc score did not correlate well with clinical outcome in ATTR\u2010CM and should not be used to assess thromboembolic risk in this population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2566","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T22:13:39Z","timestamp":1654121619000},"page":"1387-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Systemic embolism in amyloid transthyretin cardiomyopathy"],"prefix":"10.1093","volume":"24","author":[{"given":"Silvia","family":"Vilches","sequence":"first","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Fontana","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Gonzalez\u2010Lopez","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Mitrani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Saturi","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine \u2013 DIMES University of Bologna, IRCCS Sant'Orsola Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Renju","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Caponetti","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine \u2013 DIMES University of Bologna, IRCCS Sant'Orsola Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahana","family":"Gnanasampanthan","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffeny","family":"De los Santos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine \u2013 DIMES University of Bologna, IRCCS Sant'Orsola Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Rivas","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Longhi","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine \u2013 DIMES University of Bologna, IRCCS Sant'Orsola Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Rapezzi","sequence":"additional","affiliation":[{"name":"Cardiologic Center University of Ferrara  Ferrara Italy"},{"name":"Maria Cecilia Hospital, GVM Care &amp; Research  Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Gillmore","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia\u2010Pavia","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, CIBERCV  Madrid Spain"},{"name":"Universidad Francisco de Vitoria (UFV)  Pozuelo de Alarcon Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC)  Madrid Spain"},{"name":"Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab072"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.697763"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx043"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2020.1798922"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2019.12.020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018852"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.01.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.04.019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.785014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.035"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.75.4.426-b"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.073"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-019-01761-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.057"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.04.042"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304276"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.10.013"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.06.022"},{"key":"e_1_2_6_23_1","first-page":"1128","article-title":"Left atrial structure and function in cardiac amyloidosis","volume":"18","author":"Nochioka K","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2020.1810010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.742428"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2566","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2566","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:15:56Z","timestamp":1767701756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/ejhf.2566"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2566","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,11]]},"assertion":[{"value":"2021-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}