{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:59:15Z","timestamp":1792677555252,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019353","name":"Belgian Health Care Knowledge Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe the baseline characteristics of participants in the Acetazolamide in Decompensated Heart Failure with Volume Overload (ADVOR) trial and compare these with other contemporary diuretic trials in acute heart failure (AHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>ADVOR recruited 519 patients with AHF, clinically evident volume overload, elevated N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) and maintenance loop diuretic therapy prior to admission. All participants received standardized loop diuretics and were randomized towards once daily intravenous acetazolamide (500\u2009mg) versus placebo, stratified according to study centre and left ventricular ejection fraction (LVEF) (\u226440% vs. &gt;40%). The primary endpoint was successful decongestion assessed by a dedicated score indicating no more than trace oedema and no other signs of congestion after three consecutive days of treatment without need for escalating treatment. Mean age was 78\u2009years, 63% were men, mean LVEF was 43%, and median NT\u2010proBNP 6173\u2009pg\/ml. The median clinical congestion score was 4 with an EuroQol\u20105 dimensions health utility index of 0.6. Patients with LVEF \u226440% were more often male, had more ischaemic heart disease, higher levels of NT\u2010proBNP and less atrial fibrillation. Compared with diuretic trials in AHF, patients enrolled in ADVOR were considerably older with higher NT\u2010proBNP levels, reflecting the real\u2010world clinical situation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ADVOR is the largest randomized diuretic trial in AHF, investigating acetazolamide to improve decongestion on top of standardized loop diuretics. The elderly enrolled population with poor quality of life provides a good representation of the real\u2010world AHF population. The pragmatic design will provide novel insights in the diuretic treatment of patients with AHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2587","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:18:04Z","timestamp":1655943484000},"page":"1601-1610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Acetazolamide in Decompensated Heart Failure with Volume Overload trial (\n                    <scp>ADVOR<\/scp>\n                    ): baseline characteristics"],"prefix":"10.1093","volume":"24","author":[{"given":"Wilfried","family":"Mullens","sequence":"first","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk Belgium"},{"name":"Hasselt University  Diepenbeek\/Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Dauw","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk Belgium"},{"name":"Hasselt University  Diepenbeek\/Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Martens","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Meekers","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk Belgium"},{"name":"Hasselt University  Diepenbeek\/Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Nijst","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik H.","family":"Verbrugge","sequence":"additional","affiliation":[{"name":"Universitair Ziekenhuis Brussel  Jette Belgium"},{"name":"Vrije Universiteit Brussel  Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Chenot","sequence":"additional","affiliation":[{"name":"Grand H\u00f4pital de Charleroi  Charleroi Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Moubayed","sequence":"additional","affiliation":[{"name":"CHU Charleroi  Charleroi Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riet","family":"Dierckx","sequence":"additional","affiliation":[{"name":"OLV Hospital  Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Blouard","sequence":"additional","affiliation":[{"name":"Clinic Saint\u2010Luc  Bouge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Derthoo","sequence":"additional","affiliation":[{"name":"AZ Groeninge  Kortrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Smolders","sequence":"additional","affiliation":[{"name":"AZ Klina  Brasschaat Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bavo","family":"Ector","sequence":"additional","affiliation":[{"name":"Imelda Hospital  Bonheiden Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Hulselmans","sequence":"additional","affiliation":[{"name":"Ziekenhuis Maas en Kempen  Maaseik Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Lochy","sequence":"additional","affiliation":[{"name":"Universitair Ziekenhuis Brussel  Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Raes","sequence":"additional","affiliation":[{"name":"GZA Sint\u2010Augustinus  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Van Craenenbroeck","sequence":"additional","affiliation":[{"name":"Department of Cardiology Antwerp University Hospital  Edegem Belgium"},{"name":"Research Group Cardiovascular Diseases, GENCOR University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Vandekerckhove","sequence":"additional","affiliation":[{"name":"AZ Sint\u2010Lucas  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter\u2010Jan","family":"Hofkens","sequence":"additional","affiliation":[{"name":"AZ Turnhout  Turnhout Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Goossens","sequence":"additional","affiliation":[{"name":"AZ Nikolaas  Sint\u2010Niklaas Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Catherine","family":"Pouleur","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Cliniques Universitaires St Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Ceuninck","sequence":"additional","affiliation":[{"name":"AZ Delta  Roeselare Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Gabriel","sequence":"additional","affiliation":[{"name":"CHU UCL Namur  Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Timmermans","sequence":"additional","affiliation":[{"name":"Jessa Hospital  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgard A.","family":"Prihadi","sequence":"additional","affiliation":[{"name":"ZNA Hartcentrum  Antwerpen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Van Durme","sequence":"additional","affiliation":[{"name":"AZ Glorieux  Ronse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Depauw","sequence":"additional","affiliation":[{"name":"Universitair Ziekenhuis Gent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Vervloet","sequence":"additional","affiliation":[{"name":"AZ Maria Middelares  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Viaene","sequence":"additional","affiliation":[{"name":"Jan Yperman Hospital  Ieper Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Vachiery","sequence":"additional","affiliation":[{"name":"Ziekenhuis Erasme  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozine M.","family":"ter Maaten","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Bruckers","sequence":"additional","affiliation":[{"name":"Hasselt University  Diepenbeek\/Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Droogne","sequence":"additional","affiliation":[{"name":"University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Troisfontaines","sequence":"additional","affiliation":[{"name":"CHR Citadelle Hospital  Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Damman","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lassus","sequence":"additional","affiliation":[{"name":"Helsinki University Central Hospital, Heart and Lung Center and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsSpital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dupont","sequence":"additional","affiliation":[{"name":"Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0151-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2333"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1369"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.963413"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1307"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.70.3.3080630"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1478"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045691"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12127"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.35"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-02971-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.2198"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210357"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.945"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2073-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.02.057"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl193"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.566"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.682"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.069"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022972"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32520-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.762"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2021.1922195"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-1386"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht386"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00608-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000556"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft095"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050850"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.12.044"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.414"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft076"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.156547"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:16:00Z","timestamp":1767701760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,12]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/ejhf.2587"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2587","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,12]]},"assertion":[{"value":"2022-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}