{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:10:31Z","timestamp":1788487831741,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["Grant Agreement n;242209"],"award-info":[{"award-number":["Grant Agreement n;242209"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["EudraCT 2010\u2013020808\u201329"],"award-info":[{"award-number":["EudraCT 2010\u2013020808\u201329"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7\u2010242209\u2010BIOSTAT\u2010CHF"],"award-info":[{"award-number":["FP7\u2010242209\u2010BIOSTAT\u2010CHF"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Limited data exist regarding the prognostic relevance of changes in left atrial (LA) dimensions in patients with heart failure (HF). We assessed changes in LA dimension and their relation with outcomes after optimization of guideline\u2010directed medical therapy (GDMT) in patients with new\u2010onset or worsening HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Left atrial diameter was assessed at baseline and 9\u2009months after GDMT optimization in 632 patients (mean age 65.8\u2009\u00b1\u200912.1\u2009years, 22.3% female) enrolled in BIOSTAT\u2010CHF. LA adverse remodelling (LAAR) was defined as an increase in LA diameter on transthoracic echocardiography between baseline and 9 months. After the 9\u2010month visit, patients were followed for a median of 13 further months. LAAR was observed in 247 patients (39%). Larger baseline LA diameter (odds ratio [OR] 0.90; 95% confidence interval [CI] 0.87\u20130.93;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and up\u2010titration to higher doses of angiotensin\u2010converting enzyme inhibitors or angiotensin receptor blockers (ACEi\/ARBs) (OR 0.56; 95% CI 0.34\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022) were independently associated with lower likelihood of LAAR. LAAR was associated with an increased risk of the composite of all\u2010cause mortality or HF hospitalization (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007 and adjusted hazard ratio 1.73, 95% CI 1.22\u20132.45,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). The association was more pronounced in patients without a history of atrial fibrillation (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction = 0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients enrolled in BIOSTAT\u2010CHF, LAAR was associated with an unfavourable outcome and was prevented by ACEi\/ARB up\u2010titration. Changes in LA dimension may be a useful marker of response to treatment and improve risk stratification in patients with HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2593","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T03:08:51Z","timestamp":1656040131000},"page":"2131-2139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure"],"prefix":"10.1093","volume":"24","author":[{"given":"Riccardo M.","family":"Inciardi","sequence":"first","affiliation":[{"name":"Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pagnesi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo M.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Metabolism, Department of Cardiology (CVK) and Berlin\u2010Brandenburg Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK) Partner Site Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Cleland","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College  London UK"},{"name":"Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[{"name":"University of Bergen  Bergen Norway"},{"name":"Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos S.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Attikon University Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chim C.","family":"Lang","sequence":"additional","affiliation":[{"name":"School of Medicine Centre for Cardiovascular and Lung Biology, Division of Molecular and Clinical Medicine University of Dundee, Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leong L.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leicester, Glenfield Hospital  Leicester UK"},{"name":"NIHR Leicester Biomedical Research Centre, Glenfield Hospital  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Pellicori","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics and Clinical Trials University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  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