{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:41:33Z","timestamp":1791891693404,"version":"4.3.4"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007112","name":"University of Cape Town","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Peripartum cardiomyopathy (PPCM) remains a major contributor to maternal morbidity and mortality worldwide. The disease is associated with various complications occurring mainly early during its course. Reported adverse outcomes include decompensated heart failure, thromboembolic complications, arrhythmias and death. We sought to systematically and comprehensively review published literature on the management and outcome of women with PPCM across different geographical regions and to identify possible predictors of adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We performed a comprehensive search of relevant literature (2000 to June 2021) across a number of electronic databases. Cohort, case\u2010control and cross\u2010sectional studies, as well as control arms of randomized controlled trials reporting on 6\u2010 and\/or 12\u2010month outcomes of PPCM were considered eligible (PROSPERO registration: CRD42021255654). Forty\u2010seven studies (4875 patients across 60 countries) met the inclusion criteria. Haemodynamic and echocardiographic parameters were similar across all continents. All\u2010cause mortality was 8.0% (95% confidence interval [CI] 5.5\u201310.8, I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200979.1%) at 6\u2009months and 9.8% (95% CI 6.2\u201314.0, I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200980.5%) at 12\u2009months. All\u2010cause mortality was highest in Africa and Asia\/Pacific. Overall, 44.1% (95% CI 36.1\u201352.2, I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200991.7%) of patients recovered their left ventricular (LV) function within 6\u2009months and 58.7% (95% CI 48.1\u201368.9, I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200975.8%) within 12\u2009months. Europe and North America reported the highest prevalence of LV recovery. Frequent prescription of beta\u2010blocker, angiotensin\u2010converting enzyme inhibitor\/angiotensin receptor blocker and bromocriptine\/cabergoline were associated with significantly lower all\u2010cause mortality and better LV recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified significant global differences in 6\u2010 and 12\u2010month outcomes in women with PPCM. Frequent prescription of guideline\u2010directed heart failure therapy was associated with better LV recovery and lower all\u2010cause mortality. Timely initiation and up\u2010titration of heart failure therapy should therefore be strongly encouraged to improve outcome in PPCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2603","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T07:05:10Z","timestamp":1656745510000},"page":"1719-1736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["A global perspective on the management and outcomes of peripartum cardiomyopathy: a\u00a0systematic review and meta\u2010analysis"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-3026","authenticated-orcid":false,"given":"Julian","family":"Hoevelmann","sequence":"first","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"},{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes Saarland University Hospital  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-8829","authenticated-orcid":false,"given":"Mark E.","family":"Engel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Groote Schuur Hospital, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elani","family":"Muller","sequence":"additional","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Hohlfeld","sequence":"additional","affiliation":[{"name":"South African Medical Research Council  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"},{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes Saarland University Hospital  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-0911","authenticated-orcid":false,"given":"Karen","family":"Sliwa","sequence":"additional","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"},{"name":"Division of Cardiology, Groote Schuur Hospital, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"},{"name":"Department of Medicine, Groote Schuur Hospital, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-4136","authenticated-orcid":false,"given":"Charle","family":"Viljoen","sequence":"additional","affiliation":[{"name":"Cape Heart Institute, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"},{"name":"Division of Cardiology, Groote Schuur Hospital, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"},{"name":"Department of Medicine, Groote Schuur Hospital, Faculty of Health Sciences University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa455"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq120"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-054994"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1493"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.9.1183"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.11.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67760-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.768986"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_7_15_1","unstructured":"Sch\u00fcnemannH Bro\u017cekJ OxmanA editors.GRADE Handbook for Grading Quality of Evidence and Strength of Recommendation. 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