{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:49:56Z","timestamp":1793317796203,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is an increasingly diagnosed disease. Echocardiography is widely utilized, but studies to confirm the value of echocardiography for tracking changes over time are not available. We sought to describe (i) changes in multiple echocardiographic parameters; (ii) differences in rate of progression of three predominant genotypes; and (iii) the ability of changes in echocardiographic parameters to predict prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We prospectively studied 877 ATTR\u2010CM patients attending our centre between 2000 and 2020. Serial echocardiography findings at baseline, 12\u2009months and 24\u2009months were compared with survival. Overall, 565 patients had wild\u2010type ATTR\u2010CM and 312 hereditary ATTR\u2010CM (201 with V122I; 90 with T60A). There was progressive worsening of structural and functional parameters over time, patients with V122I ATTR\u2010CM showing more rapid worsening of left and right ventricular structural and functional parameters compared to both wild\u2010type and T60A ATTR\u2010CM. Among a wide range of echocardiographic analyses, including deformation\u2010based parameters, only worsening in the degree of mitral (MR) and tricuspid regurgitation (TR) at 12\u2010 and 24\u2010month assessments was associated with worse prognosis (change at 12\u2009months: MR, hazard ratio 1.43 [95% confidence interval 1.14\u20131.80],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002; TR, hazard ratio 1.38 [95% confidence interval 1.10\u20131.75],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006). Worsening in MR remained independently associated with poor prognosis after adjusting for known predictors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In ATTR\u2010CM, echocardiographic parameters progressively worsen over time. Patients with V122I ATTR\u2010CM demonstrate the most rapid deterioration. Worsening of MR and TR were the only parameters associated with mortality, MR remaining independent after adjusting for known predictors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2606","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:39:38Z","timestamp":1656761978000},"page":"1700-1712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis"],"prefix":"10.1093","volume":"24","author":[{"given":"Liza","family":"Chacko","sequence":"first","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Karia","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Venneri","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bandera","sequence":"additional","affiliation":[{"name":"Heart Failure Unit Cardiology University Department IRCCS Policlinico San Donato  Milan Italy"},{"name":"Department for Biomedical Sciences for Health University of Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice Dal","family":"Passo","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodovico","family":"Buonamici","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lazari","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Ioannou","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldostefano","family":"Porcari","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London 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Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lachmann","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Wechelakar","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Division of Medicine University College London, Royal Free Campus  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Petrie","sequence":"additional","affiliation":[{"name":"Eastman Dental Institute, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Moody","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Queen Elizabeth Hospital Birmingham University Hospitals Birmingham NHS Foundation Trust and University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Steeds","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Queen Elizabeth Hospital Birmingham University Hospitals Birmingham NHS Foundation Trust and University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Potena","sequence":"additional","affiliation":[{"name":"Division of Cardiology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Riefolo","sequence":"additional","affiliation":[{"name":"Division of Pathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna 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