{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:01:38Z","timestamp":1789005698844,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      The HFA\u2010PEFF and H\n                      <jats:sub>2<\/jats:sub>\n                      FPEF scores have been developed to diagnose heart failure with preserved ejection fraction (HFpEF), and hold prognostic value. Their value in patients with HFpEF caused by cardiac amyloidosis (CA) has never been investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We evaluated the diagnostic and prognostic value of the HFA\u2010PEFF and H\n                      <jats:sub>2<\/jats:sub>\n                      FPEF scores in 304 patients from three cohorts with HFpEF caused by transthyretin CA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0160, 53%) or immunoglobulin light\u2010chain CA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0144, 47%). A diagnosis of HFpEF was more likely using the HFA\u2010PEFF score with 2 (1%), 71 (23%), and 231 (76%) patients ranked as having a low (0\u20131), intermediate (2\u20134), or high (5, 6) probability of HFpEF, respectively. Conversely, 36 (12%), 179 (59%) and 89 (29%) of patients ranked as having a low (0\u20131), intermediate (2\u20135), or high (6\u20139) probability of HFpEF using the H\n                      <jats:sub>2<\/jats:sub>\n                      FPEF score. During a median follow\u2010up of 19\u2009months (interquartile range 8\u201340), 132 (43%) patients died. The HFA\u2010PEFF score, but not the H\n                      <jats:sub>2<\/jats:sub>\n                      FPEF score, predicted a high risk of all\u2010cause death which remained significant after adjustment for age, AL\u2010CA diagnosis, high\u2010sensitivity troponin T, N\u2010terminal pro\u2010B\u2010type natriuretic peptide, and echocardiographic parameters, including left ventricular global longitudinal strain, left ventricular diastolic function and right ventricular function (hazard ratio 1.51, 95% confidence interval 1.16\u20131.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002 for every 1\u2010point increase in HFA\u2010PEFF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The HFA\u2010PEFF score has a higher diagnostic utility in HFpEF caused by CA and holds independent prognostic value for all\u2010cause mortality, while the H\n                      <jats:sub>2<\/jats:sub>\n                      FPEF score does not.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2616","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T03:14:57Z","timestamp":1658286897000},"page":"2374-2386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Value of the\n                    <scp>HFA\u2010PEFF<\/scp>\n                    and\n                    <scp>\n                      H\n                      <sub>2<\/sub>\n                      FPEF\n                    <\/scp>\n                    scores in\u00a0patients with heart failure and preserved ejection fraction caused by cardiac amyloidosis"],"prefix":"10.1093","volume":"24","author":[{"given":"Daniela","family":"Tomasoni","sequence":"first","affiliation":[{"name":"Cardiology, ASST Spedali Civili di Brescia; Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Aimo","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Scuola Superiore Sant'Anna  Pisa Italy"},{"name":"Cardiology and Cardiovascular Medicine Division Fondazione Toscana Gabriele Monasterio  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia University of Pisa  Pisa 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