{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:13:46Z","timestamp":1789557226606,"version":"build-2803163510"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We examined the effects of istaroxime in patients hospitalized for acute heart failure (AHF) related Society for Cardiovascular Angiography and Interventions (SCAI) stage B pre\u2010cardiogenic shock (CS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Sixty patients with AHF without acute myocardial infarction with pre\u2010CS, defined as systolic blood pressure (SBP) &lt;90\u2009mmHg without hypoperfusion, venous lactate \u22652\u2009mmol\/L and\/or mechanical or inotropic support, were randomized to istaroxime 1.0\u20131.5\u00a0\u03bcg\/kg\/min or placebo for 24\u2009h. The primary endpoint, the adjusted area under the curve (AUC) change in SBP from time of treatment to 6\u00a0h, was 53.1 (standard error [SE] 6.88) mmHg\u2009\u00d7\u2009hour versus 30.9 (SE 6.76) mmHg\u2009\u00d7\u2009hour with istaroxime versus placebo (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017). Adjusted SBP AUC at 24\u2009h was 291.2 (SE 27.5) versus 208.7 (SE 27.0) mmHg\u2009\u00d7\u2009hour (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.025). At 24\u2009h, some echocardiographic measurements improved with istaroxime versus placebo including cardiac index (+0.21\u2009L\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016), left atrial area (\u22121.8\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008), and left ventricular end\u2010systolic volume (\u221212.0\u00a0ml;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034). There were no significant differences in pulse pressure, laboratory measurements, serious adverse events or adverse events between the treatment groups except for more nausea, vomiting and infusion site pain in the istaroxime\u2010treated patients. In a post\u2010hoc analysis, patients receiving \u22641.0\u00a0\u03bcg\/kg\/min versus 1.5\u00a0\u03bcg\/kg\/min had similar increase in blood pressure, but a trend towards less adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a phase 2a study of patients with AHF related pre\u2010CS, istaroxime improved blood pressure and some echocardiography measures related to heart failure and was well tolerated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2629","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T13:53:29Z","timestamp":1658498009000},"page":"1967-1977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Safety and efficacy of istaroxime in patients with acute heart failure\u2010related pre\u2010cardiogenic shock\u00a0\u2013\u00a0a multicentre, randomized, double\u2010blind, placebo\u2010controlled, parallel group study (\n                    <scp>SEISMiC<\/scp>\n                    )"],"prefix":"10.1093","volume":"24","author":[{"given":"Marco","family":"Metra","sequence":"first","affiliation":[{"name":"Cardiology Unit, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu","family":"Chioncel","sequence":"additional","affiliation":[{"name":"Emergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu'  Bucharest Romania"},{"name":"University of Medicine Carol Davila  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad","family":"Cotter","sequence":"additional","affiliation":[{"name":"Momentum Research, Inc  Chapel Hill NC USA"},{"name":"Cardiovascular Markers in Stress Conditions (MASCOT) Universit\u00e9 Paris Cit\u00e9; Inserm UMR\u2010S 942  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Davison","sequence":"additional","affiliation":[{"name":"Momentum Research, Inc  Chapel Hill NC USA"},{"name":"Cardiovascular Markers in Stress Conditions (MASCOT) Universit\u00e9 Paris Cit\u00e9; Inserm UMR\u2010S 942  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Cyprus, School of Medicine &amp; National and Kapodistrian University of Athens, School of Medicine Attikon University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"Cardiovascular Markers in Stress Conditions (MASCOT) Universit\u00e9 Paris Cit\u00e9; Inserm UMR\u2010S 942  Paris France"},{"name":"Department of Anesthesiology and Critical Care and Burn Unit, H\u00f4pital Saint\u2010Louis Lariboisi\u00e8re FHU PROMICE, DMU Parabol, APHP.Nord  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Novosadova","sequence":"additional","affiliation":[{"name":"Momentum Research, Inc  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Department of Heart Diseases Wroclaw Medical University  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Simmons","sequence":"additional","affiliation":[{"name":"Windtree Therapeutics, Inc.  Warrington PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Soffer","sequence":"additional","affiliation":[{"name":"Windtree Therapeutics, Inc.  Warrington PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Simonson","sequence":"additional","affiliation":[{"name":"Windtree Therapeutics, Inc.  Warrington PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1922"},{"key":"e_1_2_7_3_1","first-page":"e232","article-title":"Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association","volume":"136","author":"Van DS","year":"2017","journal-title":"Circulation"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00019.2006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000237"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28329"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00172-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.18.2217"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy600"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.17.1883"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.051"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1843"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1743"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.890"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:16:05Z","timestamp":1767701765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/ejhf.2629"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2629","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]},"assertion":[{"value":"2022-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}