{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:29:58Z","timestamp":1776914998593,"version":"3.51.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In AFFIRM\u2010AHF, intravenous ferric carboxymaltose (FCM) reduced heart failure (HF) hospitalisations and improved quality of life versus placebo in iron\u2010deficient patients stabilised after an acute HF episode. This analysis explored the effects of FCM versus placebo in patients with ischaemic and non\u2010ischaemic HF aetiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We included 1082 patients from AFFIRM\u2010AHF: 590 with ischaemic HF (defined as investigator\u2010reported ischaemic HF aetiology and\/or prior acute myocardial infarction and\/or prior coronary revascularisation) and 492 with non\u2010ischaemic HF. The prevalences of male sex, comorbidities, and history of HF were higher in the ischaemic versus non\u2010ischaemic HF subgroup. Annualised event rates for the primary composite outcome of total HF hospitalisations and cardiovascular death with FCM versus placebo were 65.3 versus 100.6 per 100 patient\u2010years in the ischaemic HF subgroup (rate ratio [RR] 0.65, 95% confidence interval [CI] 0.47\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007) and 58.3 versus 52.5 in the non\u2010ischaemic HF subgroup (RR 1.11, 95% CI 0.75\u20131.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.60) (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      \u00a0=\u00a00.039). An interaction between HF aetiology and treatment effect was also observed for the secondary outcome of total HF hospitalisations (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      \u00a0=\u00a00.038). A nominal increase in quality of life, assessed using the 12\u2010item Kansas City Cardiomyopathy Questionnaire, was observed with FCM versus placebo, within each subgroup.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Heart failure hospitalisations and cardiovascular deaths occurred at a higher rate in patients with ishaemic versus those with non\u2010ischaemic HF and were reduced by FCM versus placebo only in ischaemic patients. Further studies are needed to assess the role of aetiology in FCM efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2630","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T03:39:43Z","timestamp":1658547583000},"page":"1928-1939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Impact of ischaemic aetiology on the efficacy of intravenous ferric carboxymaltose in patients with iron deficiency and acute heart failure: insights from the AFFIRM\u2010AHF trial"],"prefix":"10.1093","volume":"24","author":[{"given":"Marco","family":"Metra","sequence":"first","affiliation":[{"name":"Insitute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa A.","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases Wroclaw Medical University  Poland"},{"name":"Institute of Heart Diseases University Hospital  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Pagnesi","sequence":"additional","affiliation":[{"name":"Insitute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK); and Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site Berlin; Charit\u00e9 Universit\u00e4tsmedizin Berlin  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center  Jackson MS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Dorigotti","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd  Glattbrugg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Fabien","sequence":"additional","affiliation":[{"name":"Vifor Pharma Ltd  Glattbrugg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, School of Medicine Athens University Hospital Attikon, Department of Cardiology  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget\u2010Anne","family":"Kirwan","sequence":"additional","affiliation":[{"name":"Department of Clinical Research SOCAR Research SA  Nyon Switzerland"},{"name":"London School of Hygiene and Tropical Medicine University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain C.","family":"Macdougall","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rosano","sequence":"additional","affiliation":[{"name":"Centre for Clinical and Basic Research, Department of Medical Sciences IRCCS San Raffaele Pisana  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center University Hospital Z\u00fcrich and University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Tomasoni","sequence":"additional","affiliation":[{"name":"Insitute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases Wroclaw Medical University  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the AFFIRM\u2010AHF 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