{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:37:20Z","timestamp":1791247040554,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/18\/21\/33447"],"award-info":[{"award-number":["FS\/18\/21\/33447"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is predominantly diagnosed in men. The few available studies suggest affected women have a more favourable cardiac phenotype. We aimed to characterize sex differences among consecutive patients with non\u2010hereditary and two prevalent forms of hereditary (h)ATTR\u2010CM diagnosed over a 20\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Analysis of deep phenotyping at presentation, changes on serial echocardiography and overall prognosis were evaluated. In total, 1732 consecutive patients were studied, comprising: 1095 with wild\u2010type (wt)ATTR\u2010CM; 206 with T60A\u2010hATTR\u2010CM; and 431 with V122I\u2010hATTR\u2010CM. Female prevalence was greater in T60A\u2010hATTR\u2010CM (29.6%) and V122I\u2010hATTR\u2010CM (27.8%) compared to wtATTR\u2010CM (6%). At presentation, females were 3.3\u2009years older than males (wtATTR\u2010CM: 81.9 vs. 77.8\u2009years; T60A\u2010hATTR\u2010CM: 68.7 vs. 65.1\u2009years; V122I\u2010hATTR\u2010CM: 77.1 vs. 74.9\u2009years). Body size significantly influenced measures of disease severity; when indexed, overall structural and functional phenotype was similar between sexes, the few significant differences suggested a mildly worse phenotype in females. No significant differences were observed in both disease progression on serial echocardiography and mortality across the overall population (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.459) and when divided by genotype (wtATTR\u2010CM:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.730; T60A\u2010hATTR\u2010CM:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.161; V122I\u2010hATTR\u2010CM:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.056).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study of a well\u2010characterized large cohort of ATTR\u2010CM patients did not demonstrate overall differences between sexes in either clinical phenotype, when indexed, or with respect to disease progression and prognosis. Non\u2010indexed wall thickness measurements may have contributed to both under\u2010representation and delays in diagnosis for affected females and highlights the potential role of utilizing indexed echocardiographic parameters for a more accurate assessment of patients at diagnosis and for disease prognostication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2646","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T02:24:22Z","timestamp":1659493462000},"page":"2355-2363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Sex differences among patients with transthyretin amyloid cardiomyopathy\u00a0\u2013\u00a0from diagnosis to prognosis"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-5680","authenticated-orcid":false,"given":"Rishi K.","family":"Patel","sequence":"first","affiliation":[{"name":"National Amyloidosis 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