{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:11:08Z","timestamp":1782817868642,"version":"3.54.5"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The CardioMEMS European Monitoring Study for Heart Failure (MEMS\u2010HF) investigated safety and efficacy of pulmonary artery pressure (PAP)\u2010guided remote patient management (RPM) in New York Heart Association (NYHA) class III outpatients with at least one heart failure hospitalization (HFH) during the previous 12\u2009months. This pre\u2010specified subgroup analysis investigated whether RPM effects depended on presence and subtype of pulmonary hypertension (PH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      In 106\/234 MEMS\u2010HF participants, Swan\u2013Ganz catheter tracings obtained during sensor implant were available for off\u2010line manual analysis jointly performed by two experts. Patients were classified into subgroups according to current PH definitions. Isolated post\u2010capillary PH (IpcPH) and combined post\u2010 and pre\u2010capillary PH (CpcPH) were present in 38 and 36 patients, respectively, whereas 31 patients had no PH. Clinical characteristics were comparable between subgroups, but among patients with PH pulmonary vascular resistance was higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.029) and pulmonary artery compliance lower (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.003) in patients with CpcPH. During 12\u2009months of PAP\u2010guided RPM, all PAPs declined in IpcPH and CpcPH subgroups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05), whereas only mean and diastolic PAP decreased in patients without PH (both\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05). Improvements in post\u2010 versus pre\u2010implant HFH rates were similar in CpcPH (0.639 events\/patient\u2010year; hazard ratio [HR] 0.37) and IpcPH (0.72 events\/patient\u2010year; HR 0.45) patients. Participants without PH benefited most (0.26 events\/patient\u2010year; HR 0.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.04 vs. IpcPH\/CpcPH patients). Quality of life and NYHA class improved significantly in all subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Outpatients with NYHA class III symptoms with at least one HFH during 1\u2009year pre\u2010implant benefitted significantly from PAP\u2010guided RPM during post\u2010implant follow\u2010up irrespective of presence or subtype of PH at baseline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2656","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T23:33:17Z","timestamp":1661297597000},"page":"2320-2330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of remote haemodynamic\u2010guided heart failure management in patients with different subtypes of pulmonary hypertension: insights from the\n                    <scp>MEMS\u2010HF<\/scp>\n                    study"],"prefix":"10.1093","volume":"24","author":[{"given":"Birgit","family":"Assmus","sequence":"first","affiliation":[{"name":"Cardiology, Department of Medicine Goethe University Hospital  Frankfurt Germany"},{"name":"Medical Clinic I, Department of Cardiology, University Hospital Giessen Justus Liebig University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane E.","family":"Angermann","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Alkhlout","sequence":"additional","affiliation":[{"name":"Klinikum Karlsburg Heart and Diabetes Center Mecklenburg\u2010Western Pommerania  Karlsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert W.","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Division Heart &amp; Lungs, Department of Cardiology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Schnupp","sequence":"additional","affiliation":[{"name":"Medical Centre Coburg GmbH II, Medical Clinic Cardiology, Angiology, Pulmonology  Coburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper J.","family":"Brugts","sequence":"additional","affiliation":[{"name":"Thorax Center Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nordbeck","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Cardiology, Department of Medicine I, Centre for Internal Medicine University Hospital W\u00fcrzburg  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