{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:45:52Z","timestamp":1794336352203,"version":"4.9.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is increasingly recognized as a cause of heart failure in the elderly. Although wild\u2010type transthyretin amyloidosis is the most frequent form of ATTR\u2010CM found in the elderly, hereditary transthyretin amyloidosis (ATTRv) can also occur. We sought to determine the prevalence of ATTRv among elderly ATTR\u2010CM patients, identify predictors of ATTRv and evaluate the clinical consequences of positive genetic testing in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Prevalence of ATTRv in elderly ATTR\u2010CM patients (\u226570\u2009years) was assessed in a cohort of 300 consecutive ATTR\u2010CM patients (median age 78\u2009years at diagnosis, 82% \u226570\u2009years, 16% female, 99% Caucasian). ATTRv was diagnosed in 35 (12%; 95% confidence interval [CI] 3.1\u20138.8) and 13 (5.3%; 95% CI 5.6\u201326.7) patients in the overall cohort and in those \u226570\u2009years, respectively. Prevalence of ATTRv among elderly female patients with ATTR\u2010CM was 13% (95% CI 2.1\u201323.5). Univariate analysis identified female sex (odds ratio [OR] 3.66; 95% CI 1.13\u201311.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03), black ancestry (OR 46.31; 95% CI 3.52\u2013Inf;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), eye symptoms (OR 6.64; 95% CI 1.20\u201336.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) and polyneuropathy (OR 10.05; 95% CI 3.09\u201332.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) as the only factors associated with ATTRv in this population. Diagnosis of ATTRv in elderly ATTR\u2010CM patients allowed initiation of transthyretin\u2010specific drug treatment in 5 individuals, genetic screening in 33 relatives from 13 families, and identification of 9 ATTRv asymptomatic carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hereditary transthyretin amyloidosis is present in a substantial number of ATTR\u2010CM patients aged \u226570\u2009years. Identification of ATTRv in elderly patients with ATTR\u2010CM has clinical meaningful therapeutic and diagnostic implications. These results support routine genetic testing in patients with ATTR\u2010CM regardless of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2658","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T23:33:29Z","timestamp":1661297609000},"page":"2367-2373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Frequency of hereditary transthyretin amyloidosis among elderly patients with transthyretin cardiomyopathy"],"prefix":"10.1093","volume":"24","author":[{"given":"Alba","family":"Maestro\u2010Benedicto","sequence":"first","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"},{"name":"IIB Sant Pau  Barcelona Spain"},{"name":"Heart Failure and Transplant Unit, Department of Cardiology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Vela","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"de Frutos","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Mora","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Pomares","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Gonzalez\u2010Vioque","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cobo\u2010Marcos","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Gonzalez\u2010Lopez","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Segovia","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Lara\u2010Pezzi","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia\u2010Pavia","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV  Madrid Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC)  Madrid Spain"},{"name":"Universidad Francisco de Vitoria (UFV)  Pozuelo de Alarc\u00f3n Spain"},{"name":"Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab072"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.08.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv338"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx350"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038169"},{"key":"e_1_2_6_7_1","first-page":"149","article-title":"Clinical profile and outcome of cardiac amyloidosis in a Spanish referral center","volume":"74","author":"L\u00f3pez\u2010Sainz \u00c1","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.04.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-10010-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.596"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000290"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.09.011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404852"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejhf.2658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejhf.2658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:16:13Z","timestamp":1767701773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.2658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,11]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/ejhf.2658"],"URL":"https:\/\/doi.org\/10.1002\/ejhf.2658","archive":["Portico"],"relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,11]]},"assertion":[{"value":"2022-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}