{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:44:47Z","timestamp":1790912687718,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Heart Fail"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Right ventricular dysfunction (RVD), as expressed by right ventricular to pulmonary artery coupling, has recently been identified as a strong outcome predictor in patients undergoing mitral valve edge\u2010to\u2010edge repair (M\u2010TEER) for secondary mitral regurgitation (MR). The aim of this study was to define RVD in patients undergoing M\u2010TEER for primary MR (PMR) and to evaluate its impact on procedural MR reduction, symptomatic development and 2\u2010year all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      This multicentre study included patients undergoing M\u2010TEER for symptomatic PMR at nine international centres. The study cohort was divided into a derivation (DC) and validation cohort (VC) for calculation and validation of the best discriminatory value for RVD. A total of 648 PMR patients were included in the study. DC and VC were comparable regarding procedural success and outcomes at follow\u2010up. Sensitivity analysis identified RVD as an independent predictor for 2\u2010year mortality in the DC (hazard ratio [HR] 2.37, 95% confidence interval [CI] 1.47\u20133.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), which was confirmed in the VC (HR 2.06, 95% CI 1.36\u20133.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Procedural success (MR \u22642+) and symptomatic improvement at follow\u2010up (New York Heart Association [NYHA] class \u2264II) were lower in PMR patients with RVD (MR \u22642+: 82% vs. 93%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002; NYHA class \u2264II: 57.3% vs. 66.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.09 for with vs. without RVD). In all PMR patients, the presence of RVD significantly impaired 2\u2010year survival after M\u2010TEER (HR 2.23, 95% CI 1.63\u20133.05,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mitral valve edge\u2010to\u2010edge repair is an effective treatment option for PMR patients. The presence of RVD is associated with less MR reduction, less symptomatic improvement and increased 2\u2010year mortality. Accordingly, RVD might be included into pre\u2010procedural prognostic considerations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2661","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T23:43:28Z","timestamp":1661298208000},"page":"2162-2171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Right ventricular dysfunction predicts outcome after transcatheter mitral valve repair for\u00a0primary mitral valve regurgitation"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5700-4799","authenticated-orcid":false,"given":"Philipp M.","family":"Doldi","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Klinikum der Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"Munich Heart Alliance Partner Site German Center for Cardiovascular Disease (DZHK)  Munich 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Hamburg\/L\u00fcbeck\/Kiel  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Geyer","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Kardiologie Johannes Gutenberg\u2010Universit\u00e4t  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/L\u00fcbeck\/Kiel  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Orban","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Klinikum der Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"Munich Heart Alliance Partner Site German Center for Cardiovascular Disease (DZHK)  Munich 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