{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:06:38Z","timestamp":1787756798616,"version":"build-2784847793"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We assessed the incidence, predictors and clinical correlates of de-novo aortic regurgitation (AR), which physiologically reduces left ventricular assist device (LVAD) effectiveness due to recirculation syndrome, in the MOMENTUM 3 trial portfolio of the fully magnetically levitated HeartMate 3 (HM3) pump using the randomized pivotal trial (PT) and post-trial continued access protocol (CAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>De-novo aortic regurgitation incidence at 2\u2009years was analysed in the randomized PT and validated in the first 1000 implanted patients of the CAP. Patients with concomitant\/prior aortic valve surgery or without baseline or post-implant echocardiograms were excluded from this analysis. AR severity was assessed qualitatively by site-adjudicated echocardiograms (significant AR was defined as moderate or severe grade on echocardiogram). Of 1028 patients enrolled in the PT, 918 were eligible for inclusion in this analysis (HM3, n =\u2009465; HMII, n = 453). At 2\u2009years of LVAD support, freedom from significant AR was greater in the HM3 (92%) than HMII (82%) (hazard ratio 0.45, 95% confidence interval 0.27\u20130.75, p &amp;lt;\u20090.01). Of 907 HM3 patients analysed from the first 1000 implanted CAP patients, the rate of freedom from significant AR was 90%, consistent with the PT (p =\u20090.3). In the combined HM3 group (n =\u20091372), multivariable Cox modelling identified increasing age and female sex as significant predictors. Survival free of urgent transplant or AR corrective procedure was similar between HM3 patients with and without significant de-novo AR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The development of moderate or severe grade de-novo AR is reduced with the fully magnetically levitated HM3 LVAD compared to the axial-flow HMII pump. The occurrence of significant de-novo AR with the HM3 pump is not associated with a worse outcome at 2\u2009years of follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.2746","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T23:40:05Z","timestamp":1668987605000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Incidence and Clinical Correlates of\n                    <i>de-novo<\/i>\n                    Aortic Regurgitation with a Fully Magnetically Levitated Left Ventricular Assist Device: A MOMENTUM 3 Trial Portfolio Analysis"],"prefix":"10.1093","volume":"25","author":[{"given":"Nir","family":"Uriel","sequence":"first","affiliation":[{"name":"Division of Cardiology, Columbia University Irving Medical Center , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Milano","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center , Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Section of Advanced Heart Failure and Cardiac Transplantation, Division of Cardiology, Duke University Medical Center , Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Medicine, Advanced Heart Failure and Transplantation, Spectrum Health Meijer Heart & Vascular Institute , Grand Rapids, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado Health Sciences Center , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Montefiore Einstein Center for Heart and Vascular Care , Bronx, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AiJia","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics \u2013 Heart Failure, Abbott , Burlington, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Crandall","sequence":"additional","affiliation":[{"name":"Global Clinical Affairs \u2013 Heart Failure, Abbott , Pleasanton, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep R.","family":"Mehra","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Center for Advanced Heart Disease, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"2026010913081317600_ejhf2746-bib-0001","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.healun.2015.10.022","article-title":"Development of de novo aortic valve incompetence in patients with the continuous-flow HeartWare ventricular assist device","volume":"35","author":"Bhagra","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"2026010913081317600_ejhf2746-bib-0002","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/CIRCHEARTFAILURE.109.917765","article-title":"The development of aortic 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