{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:52:03Z","timestamp":1792270323458,"version":"4.4.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology","award":["2012M3A9C7050140 and 2012R1A2A2A02012821"],"award-info":[{"award-number":["2012M3A9C7050140 and 2012R1A2A2A02012821"]}]},{"name":"the Korean Society of Heart Failure, and the Korean Society of Cardiology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In acute heart failure (AHF) patients, pulmonary oedema and low tissue perfusion may lead to changes in the acid\u2013base balance, which may be associated with worse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this prospective nationwide cohort study from 24 academic hospitals, arterial blood gas (ABG) was measured in 1982 AHF patients at hospital admission. Acidosis was defined as pH &amp;lt;7.36, and alkalosis as pH &amp;gt;7.44. Mortality was stratified according to ABG results. Overall, 19% had acidosis, 37% had normal pH, and 44% had alkalosis. The most common type of acidosis was the mixed type (42%) followed by metabolic acidosis (40%), and the most common type of alkalosis was respiratory alkalosis (58%). At 12 months\u2019 follow-up 304 patients (15%) died. Patients with acidosis had higher mortality (acidosis 19.5%, neutral pH 13.7%, alkalosis 14.9%; P = 0.007). In the Cox proportional-hazards regression model, acidosis was a significant predictor of mortality (hazard ratio 1.93; 95% confidence intervals 1.27\u20132.93) along with N-terminal pro-brain type natriuretic peptide (NT-proBNP), among others. In contrast, alkalosis was not associated with increased mortality. pH had an incremental prognostic value over NT-proBNP (net reclassification improvement 30%; P &amp;lt; 0.001), and ABG analysis identified extra patients at increased risk for mortality among patients with an NT-proBNP level less than the median (12-month mortality 17.5% vs. 9.9%; P = 0.009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In high-risk AHF patients, the most common acid\u2013base imbalance is respiratory alkalosis. Acidosis is observed in every fifth patient and is a significant predictor of mortality. pH provides an additional prognostic value and may be used to optimize risk stratification in high-risk AHF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejhf.276","type":"journal-article","created":{"date-parts":[[2015,6,21]],"date-time":"2015-06-21T00:58:19Z","timestamp":1434848299000},"page":"601-611","source":"Crossref","is-referenced-by-count":54,"title":["The Prognostic Value of Arterial Blood Gas Analysis in High-Risk Acute Heart Failure Patients: An Analysis of the Korean Heart Failure (KorHF) Registry"],"prefix":"10.1093","volume":"17","author":[{"given":"Jin Joo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital , Seongnam 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Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"the Medical Research Collaborating Centre, Seoul National University Bundang Hospital , Seongnam ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Ahn","sequence":"additional","affiliation":[{"name":"the Medical Research Collaborating Centre, Seoul National University Bundang Hospital , Seongnam ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Su","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Yonsei University Wonju Severance Christian Hospital , Wonju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Yonsei University Severance Hospital , Seoul 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